Literature DB >> 24556809

Mitofusins: ubiquitylation promotes fusion.

Mafalda Escobar-Henriques1.   

Abstract

Mitochondrial genes including Mfn2 are at the center of many diseases, underscoring their potential as a therapeutical target. The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30, acting on Mfn1 and Mfn2.

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Year:  2014        PMID： 24556809      PMCID： PMC3975502          DOI： 10.1038/cr.2014.23

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  11 in total

1.  Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.

Authors:  Lixia Zhao; Feng He; Haiyang Liu; Yushan Zhu; Weili Tian; Ping Gao; Hongping He; Wen Yue; Xiaobo Lei; Biyun Ni; Xiaohui Wang; Haijing Jin; Xiaojiang Hao; Jialing Lin; Quan Chen
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

2.  A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/β-catenin signaling and colon cancer cell tumorigenesis.

Authors:  Wei Wang; Haiyang Liu; Sheng Wang; Xiaojiang Hao; Lin Li
Journal:  Cell Res       Date:  2011-02-15       Impact factor: 25.617

Review 3.  The ubiquitin code.

Authors:  David Komander; Michael Rape
Journal:  Annu Rev Biochem       Date:  2012-04-10       Impact factor: 23.643

4.  Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.

Authors:  Nobuhiro Nakamura; Shigehisa Hirose
Journal:  Mol Biol Cell       Date:  2008-02-20       Impact factor: 4.138

5.  Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion.

Authors:  Mickael M J Cohen; Guillaume P Leboucher; Nurit Livnat-Levanon; Michael H Glickman; Allan M Weissman
Journal:  Mol Biol Cell       Date:  2008-03-19       Impact factor: 4.138

6.  Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways.

Authors:  Fabian Anton; Gunnar Dittmar; Thomas Langer; Mafalda Escobar-Henriques
Journal:  Mol Cell       Date:  2013-01-11       Impact factor: 17.970

Review 7.  Mechanistic perspective of mitochondrial fusion: tubulation vs. fragmentation.

Authors:  Mafalda Escobar-Henriques; Fabian Anton
Journal:  Biochim Biophys Acta       Date:  2012-08-05

8.  Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.

Authors:  Guillaume P Leboucher; Yien Che Tsai; Mei Yang; Kristin C Shaw; Ming Zhou; Timothy D Veenstra; Michael H Glickman; Allan M Weissman
Journal:  Mol Cell       Date:  2012-06-28       Impact factor: 17.970

9.  The intracellular redox state is a core determinant of mitochondrial fusion.

Authors:  Timothy Shutt; Michèle Geoffrion; Ross Milne; Heidi M McBride
Journal:  EMBO Rep       Date:  2012-09-04       Impact factor: 8.807

10.  Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.

Authors:  Atsushi Tanaka; Megan M Cleland; Shan Xu; Derek P Narendra; Der-Fen Suen; Mariusz Karbowski; Richard J Youle
Journal:  J Cell Biol       Date:  2010-12-20       Impact factor: 10.539
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  8 in total

Review 1.  Regulation of mitochondrial inner membrane fusion: divergent evolution with similar solutions?

Authors:  Johannes Wagener
Journal:  Curr Genet       Date:  2015-11-27       Impact factor: 3.886

2.  microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor.

Authors:  Heejin Lee; Hyosun Tak; So Jung Park; Yoon Kyung Jo; Dong Hyung Cho; Eun Kyung Lee
Journal:  BMB Rep       Date:  2017-04       Impact factor: 4.778

3.  Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition.

Authors:  Vincent Anton; Ira Buntenbroich; Ramona Schuster; Felix Babatz; Tânia Simões; Selver Altin; Gaetano Calabrese; Jan Riemer; Astrid Schauss; Mafalda Escobar-Henriques
Journal:  Life Sci Alliance       Date:  2019-11-18

Review 4.  Targeting Mitochondrial Network Architecture in Down Syndrome and Aging.

Authors:  Nunzia Mollo; Rita Cicatiello; Miriam Aurilia; Roberta Scognamiglio; Rita Genesio; Maria Charalambous; Simona Paladino; Anna Conti; Lucio Nitsch; Antonella Izzo
Journal:  Int J Mol Sci       Date:  2020-04-29       Impact factor: 5.923

5.  Effects of prenatal photobiomodulation treatment on neonatal hypoxic ischemia in rat offspring.

Authors:  Luodan Yang; Yan Dong; Chongyun Wu; Hannah Youngblood; Yong Li; Xuemei Zong; Lei Li; Tongda Xu; Quanguang Zhang
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

Review 6.  Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease.

Authors:  Fouzi El Magraoui; Christina Reidick; Hemut E Meyer; Harald W Platta
Journal:  Cells       Date:  2015-10-05       Impact factor: 6.600

Review 7.  Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease.

Authors:  Sentiljana Gumeni; Ioannis P Trougakos
Journal:  Oxid Med Cell Longev       Date:  2016-02-09       Impact factor: 6.543

Review 8.  Mitochondrial Surveillance by Cdc48/p97: MAD vs. Membrane Fusion.

Authors:  Mafalda Escobar-Henriques; Vincent Anton
Journal:  Int J Mol Sci       Date:  2020-09-18       Impact factor: 5.923
  8 in total

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