Nao Suzuki1, Masahiro Yoneda2, Kazunari Tanabe3, Akie Fujimoto4, Kosaku Iha4, Kei Seno4, Kazuhiko Yamada4, Tomoyuki Iwamoto4, Yosuke Masuo4, Takao Hirofuji4. 1. Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan. Electronic address: naojsz@college.fdcnet.ac.jp. 2. Center for Oral Diseases, Fukuoka Dental College, Fukuoka, Japan. 3. Tanabe Preservative Dentistry, Fukuoka, Japan. 4. Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan.
Abstract
OBJECTIVE: This study evaluated the effect of probiotic intervention using lactobacilli on oral malodor. STUDY DESIGN: We conducted a 14-day, double-blind, placebo-controlled, randomized crossover trial of tablets containing Lactobacillus salivarius WB21 (2.0 × 10(9) colony-forming units per day) or placebo taken orally by patients with oral malodor. RESULTS:Organoleptic test scores significantly decreased in both the probiotic and placebo periods compared with the respective baseline scores (P < .001 and P = .002), and no difference was detected between periods. In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period. Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) and Fusobacterium nucleatum (P = .020) in the probiotic period. CONCLUSIONS: These results indicated that daily oral consumption of tablets containing probiotic lactobacilli could help to control oral malodor and malodor-related factors.
RCT Entities:
OBJECTIVE: This study evaluated the effect of probiotic intervention using lactobacilli on oral malodor. STUDY DESIGN: We conducted a 14-day, double-blind, placebo-controlled, randomized crossover trial of tablets containing Lactobacillus salivarius WB21 (2.0 × 10(9) colony-forming units per day) or placebo taken orally by patients with oral malodor. RESULTS: Organoleptic test scores significantly decreased in both the probiotic and placebo periods compared with the respective baseline scores (P < .001 and P = .002), and no difference was detected between periods. In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period. Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) and Fusobacterium nucleatum (P = .020) in the probiotic period. CONCLUSIONS: These results indicated that daily oral consumption of tablets containing probiotic lactobacilli could help to control oral malodor and malodor-related factors.
Authors: Arantxa López-López; Anny Camelo-Castillo; María D Ferrer; Áurea Simon-Soro; Alex Mira Journal: Front Microbiol Date: 2017-03-10 Impact factor: 5.640