Taihei Hayakawa1, Minao Furumura2, Hideo Fukano3, Xiaoguang Li4, Norito Ishii5, Takahiro Hamada5, Chika Ohata2, Daisuke Tsuruta6, Kazuo Shimozato7, Takashi Hashimoto8. 1. Postgraduate Researcher, Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan; Postgraduate Student, Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan. 2. Associate Professor, Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan. 3. Associate Professor, Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan. 4. Postdoctoral Researcher, Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan. 5. Senior Lecturer, Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan. 6. Professor, Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan. 7. Professor, Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan. 8. Professor, Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan. Electronic address: hashimot@med.kurume-u.ac.jp.
Abstract
OBJECTIVE: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease caused by various autoantibodies. This study aimed to evaluate the diagnostic value of MMP-specific autoantibodies in patient sera. STUDY DESIGN: We analyzed sera from 30 MMP-suspected patients with intractable oral mucosal lesions using a combination of indirect immunofluorescence with 1M NaCl-split skin, immunoblot analysis, and ELISAs. We also analyzed clinical features among different types of MMP. RESULTS: Seventeen, 4, and 3 patients were diagnosed with anti-BP180-type MMP, anti-laminin-332-type MMP, and combined anti-BP180/anti-laminin-332-type MMP, respectively. CONCLUSIONS: Our results indicated that a combination of immunologic testing for circulating autoantibodies is useful for the diagnosis of MMP.
OBJECTIVE: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease caused by various autoantibodies. This study aimed to evaluate the diagnostic value of MMP-specific autoantibodies in patient sera. STUDY DESIGN: We analyzed sera from 30 MMP-suspected patients with intractable oral mucosal lesions using a combination of indirect immunofluorescence with 1M NaCl-split skin, immunoblot analysis, and ELISAs. We also analyzed clinical features among different types of MMP. RESULTS: Seventeen, 4, and 3 patients were diagnosed with anti-BP180-type MMP, anti-laminin-332-type MMP, and combined anti-BP180/anti-laminin-332-type MMP, respectively. CONCLUSIONS: Our results indicated that a combination of immunologic testing for circulating autoantibodies is useful for the diagnosis of MMP.
Authors: H Rashid; A Lamberts; L Borradori; S Alberti-Violetti; R J Barry; M Caproni; B Carey; M Carrozzo; F Caux; G Cianchini; A Corrà; G F H Diercks; F G Dikkers; G Di Zenzo; C Feliciani; G Geerling; G Genovese; M Hertl; P Joly; A V Marzano; J M Meijer; V Mercadante; D F Murrell; M Ormond; H H Pas; A Patsatsi; C Prost; S Rauz; B D van Rhijn; M Roth; E Schmidt; J Setterfield; G Zambruno; D Zillikens; B Horváth Journal: J Eur Acad Dermatol Venereol Date: 2021-07-10 Impact factor: 6.166