| Literature DB >> 24556440 |
Véronique Marthiens1, Renata Basto2.
Abstract
Centrosome mutations associated with microcephaly are normally thought to result in loss-of-function phenotypes. A new study shows, however, that mutations found in the human microcephaly STIL gene cause centrosome amplification, suggesting a direct link between the presence of extra centrosomes and the establishment of this disease.Entities:
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Year: 2014 PMID： 24556440 DOI： 10.1016/j.cub.2013.12.054
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834