| Literature DB >> 24556144 |
Zhen-Yuan Zhu1, Wan-Xiao Wang2, Zhen-qian Wang2, Li-Jing Chen3, Jing-Yi Zhang2, Xiao-Cui Liu2, Shao-ping Wu4, Yong-Min Zhang4.
Abstract
A series of 5,7-disubstituted chrysin, 7-monosubstituted chrysin, 5-monosubstituted chrysin derivatives were synthesized by alkylation, acetylation, benzoylation, carboxymethylation, and evaluated on their antitumor activity of H22 cells in the search for potential antitumor agents. Among them, compound 3 (5,7-diacetyl chrysin) displayed the most potent antitumor activity with IC50 value of 141 μM. Moreover, there is significant up-regulation of G2 in cell cycle of H22.Entities:
Keywords: Active sites; Antitumor agents; Chrysin derivatives; H22; Inhibition of cell division
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Year: 2014 PMID： 24556144 DOI： 10.1016/j.ejmech.2013.12.044
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514