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Literature DB >> 24554661

Role of the immunoreceptor tyrosine-based activation motif of latent membrane protein 2A (LMP2A) in Epstein-Barr virus LMP2A-induced cell transformation.

Abstract

Latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV) is widely expressed in EBV-associated malignancies. We demonstrate that LMP2A has a transformation ability. This study shows that LMP2A-induced transformation in several human nonhematopoietic cell lines was blocked in those cells expressing an immunoreceptor tyrosine-based activation motif (ITAM) LMP2A mutant. The Syk inhibitor or Syk-specific small interfering RNA (siRNA) inhibited LMP2A-induced transformation. These results indicate that the interaction of the LMP2A ITAM with Syk is a key step for LMP2A-mediated transformation.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 24554661 PMCID： PMC3993816 DOI： 10.1128/JVI.03714-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

37 in total

1. Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.

Authors: F Scholle; K M Bendt; N Raab-Traub
Journal: J Virol Date: 2000-11 Impact factor: 5.103

2. Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway.

Authors: R Swart; I K Ruf; J Sample; R Longnecker
Journal: J Virol Date: 2000-11 Impact factor: 5.103

Review 3. Oncogenic kinase signalling.

Authors: P Blume-Jensen; T Hunter
Journal: Nature Date: 2001-05-17 Impact factor: 49.962

4. SYK inhibition and response prediction in diffuse large B-cell lymphoma.

Authors: Shuhua Cheng; Greg Coffey; X Hannah Zhang; Rita Shaknovich; Zibo Song; Pin Lu; Anjali Pandey; Ari M Melnick; Uma Sinha; Y Lynn Wang
Journal: Blood Date: 2011-10-24 Impact factor: 22.113

5. Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

Authors: G Winberg; L Matskova; F Chen; P Plant; D Rotin; G Gish; R Ingham; I Ernberg; T Pawson
Journal: Mol Cell Biol Date: 2000-11 Impact factor: 4.272

Review 6. Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?

Authors: R Longnecker
Journal: Adv Cancer Res Date: 2000 Impact factor: 6.242

7. Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A in perinuclear regions in transiently transfected cells.

Authors: David T Lynch; Jeffrey S Zimmerman; David T Rowe
Journal: J Gen Virol Date: 2002-05 Impact factor: 3.891

8. Analysis of the phosphorylation status of Epstein-Barr virus LMP2A in epithelial cells.

Authors: F Scholle; R Longnecker; N Raab-Traub
Journal: Virology Date: 2001-12-20 Impact factor: 3.616

9. Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through αv-integrin membrane translocation.

Authors: Julie A Fotheringham; Nicole E Coalson; Nancy Raab-Traub
Journal: J Virol Date: 2012-07-25 Impact factor: 5.103

10. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis.

Authors: G Bannish; E M Fuentes-Pananá; J C Cambier; W S Pear; J G Monroe
Journal: J Exp Med Date: 2001-12-03 Impact factor: 14.307

5 in total

Review 1. Manipulation of the host cell membrane by human γ-herpesviruses EBV and KSHV for pathogenesis.

Authors: Fang Wei; Qing Zhu; Ling Ding; Qing Liang; Qiliang Cai
Journal: Virol Sin Date: 2016-09-12 Impact factor: 4.327

Review 2. Epstein-Barr virus latent genes.

Authors: Myung-Soo Kang; Elliott Kieff
Journal: Exp Mol Med Date: 2015-01-23 Impact factor: 8.718