Katie M Lavigne1, Lucile A Rapin2, Paul D Metzak1, Jennifer C Whitman1, Kwanghee Jung3, Marion Dohen4, Hélène Lœvenbruck5, Todd S Woodward6. 1. Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; BC Mental Health and Addictions Research Institute, Provincial Health Services Authority, Vancouver, BC, Canada; 2. Department of Linguistics, Université du Québec à Montréal, Montréal, QC, Canada; 3. Department of Pediatrics, University of Texas Health Science Center, Houston, TX; 4. Speech and Cognition Department, Grenoble University, Grenoble, France; 5. LPNC, CNRS UMR 5105, Université Grenoble Alpes, Grenoble, France. 6. Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; BC Mental Health and Addictions Research Institute, Provincial Health Services Authority, Vancouver, BC, Canada; todd.woodward@ubc.ca.
Abstract
BACKGROUND: Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS: In the current study, we used a task that allowed experimental manipulation of control over verbal material and compared brain activity between 23 schizophrenia patients (10 hallucinators, 13 nonhallucinators), 22 psychiatric (bipolar), and 27 healthy controls. Two conditions were presented, one involving inner verbal thought (in which control over verbal material was required) and another involving speech perception (SP; in which control verbal material was not required). RESULTS: A functional connectivity analysis resulted in a left-dominant temporal-frontal network that included speech-related auditory and motor regions and showed hypercoupling in past-week hallucinating schizophrenia patients (relative to nonhallucinating patients) during SP only. CONCLUSIONS: These findings replicate our previous work showing generalized speech-related functional network hypercoupling in schizophrenia during inner verbal thought and SP, but extend them by suggesting that hypercoupling is related to past-week hallucination severity scores during SP only, when control over verbal material is not required. This result opens the possibility that practicing control over inner verbal thought processes may decrease the likelihood or severity of hallucinations.
BACKGROUND: Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS: In the current study, we used a task that allowed experimental manipulation of control over verbal material and compared brain activity between 23 schizophreniapatients (10 hallucinators, 13 nonhallucinators), 22 psychiatric (bipolar), and 27 healthy controls. Two conditions were presented, one involving inner verbal thought (in which control over verbal material was required) and another involving speech perception (SP; in which control verbal material was not required). RESULTS: A functional connectivity analysis resulted in a left-dominant temporal-frontal network that included speech-related auditory and motor regions and showed hypercoupling in past-week hallucinating schizophreniapatients (relative to nonhallucinating patients) during SP only. CONCLUSIONS: These findings replicate our previous work showing generalized speech-related functional network hypercoupling in schizophrenia during inner verbal thought and SP, but extend them by suggesting that hypercoupling is related to past-week hallucination severity scores during SP only, when control over verbal material is not required. This result opens the possibility that practicing control over inner verbal thought processes may decrease the likelihood or severity of hallucinations.
Authors: Vincent G van de Ven; Elia Formisano; Christian H Röder; David Prvulovic; Robert A Bittner; Matthias G Dietz; Daniela Hubl; Thomas Dierks; Andrea Federspiel; Fabrizio Esposito; Francesco Di Salle; Bernadette Jansma; Rainer Goebel; David E J Linden Journal: Neuroimage Date: 2005-09 Impact factor: 6.556
Authors: Todd S Woodward; Christine M Tipper; Alexander L Leung; Katie M Lavigne; Nicole Sanford; Paul D Metzak Journal: Hum Brain Mapp Date: 2015-05-25 Impact factor: 5.038
Authors: Todd S Woodward; Kwanghee Jung; Heungsun Hwang; John Yin; Laura Taylor; Mahesh Menon; Emmanuelle Peters; Elizabeth Kuipers; Flavie Waters; Tania Lecomte; Iris E Sommer; Kirstin Daalman; Remko van Lutterveld; Daniela Hubl; Jochen Kindler; Philipp Homan; Johanna C Badcock; Saruchi Chhabra; Matteo Cella; Sarah Keedy; Paul Allen; Andrea Mechelli; Antonio Preti; Sara Siddi; David Erickson Journal: Schizophr Bull Date: 2014-07 Impact factor: 9.306