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Literature DB >> 24552542

In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities.

Xiamin Cheng¹, Lin Li, Mahesh Uttamchandani, Shao Q Yao.

Abstract

A library of cell-permeable, minimally tagged C75 analogues was synthesized and used to uncover biological targets in human liver cancer cells. Known targets of C75, namely FASN and CPT1A, together with other unknown targets, including PDIA3, TFRC, and GAPDH, were thus identified.

Entities: Disease Gene Species

Mesh：

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Year: 2014 PMID： 24552542 DOI： 10.1021/ol500206w

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

8 in total

1. Total Synthesis and Structural Elucidation of Two Unusual Non-Methylene-Interrupted Fatty Acids in Ovaries of the Limpet Cellana toreuma.

Authors: Kazuaki Shimada; Ayako Sugawara; Toshinobu Korenaga; Hideki Kawashima
Journal: Lipids Date: 2017-09-27 Impact factor: 1.880

2. [6]-Gingerol inhibits de novo fatty acid synthesis and carnitine palmitoyltransferase-1 activity which triggers apoptosis in HepG2.

Authors: Hathaichanok Impheng; Lysiane Richert; Dumrongsak Pekthong; C Norman Scholfield; Sutatip Pongcharoen; Ittipon Pungpetchara; Piyarat Srisawang
Journal: Am J Cancer Res Date: 2015-03-15 Impact factor: 6.166

In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities.

1. Total Synthesis and Structural Elucidation of Two Unusual Non-Methylene-Interrupted Fatty Acids in Ovaries of the Limpet Cellana toreuma.

2. [6]-Gingerol inhibits de novo fatty acid synthesis and carnitine palmitoyltransferase-1 activity which triggers apoptosis in HepG2.

Review 3. Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.

4. Diels-Alder Reactions of Furans with Itaconic Anhydride: Overcoming Unfavorable Thermodynamics.

Review 5. Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.

6. Fatty Acid Synthase Contributes to Restimulation-Induced Cell Death of Human CD4 T Cells.

Review 7. Fatty Acid Synthase: An Emerging Target in Cancer.

8. USP14 Regulates Cancer Cell Growth in a Fatty Acid Synthase-Independent Manner.