CONTEXT: Self-rated health and health-related quality of life are inversely associated with increased morbidity and mortality; however, the temporal relationship with reproductive hormones is poorly understood. OBJECTIVES: The objective of the study was to examine relationships between reproductive hormones, self-rated health, and quality of life in older men at baseline as well as changes over a 2-year follow-up. DESIGN, SETTING, AND PARTICIPANTS: One thousand six hundred thirty-seven men aged 70 years and older from the Concord Health and Ageing in Men Project were assessed at baseline and 1316 men returned for the 2-year follow-up. Serum T, dihydrotestosterone, estradiol, and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry and SHBG, LH, and FSH by immunoassay. Logistic regression and multivariate linear regression models were performed. OUTCOME MEASURES: Self-rated health and health-related quality of life measures (12-Item Short Form Health Survey) were determined. RESULTS: In the cross-sectional baseline data, univariate analyses revealed significant associations between many of the hormones and quality-of-life scores and self-rated health. In a multivariable analysis, the associations between T, E1, and calculated free T and self-rated health remained statistically significant. Compared with men in the highest T quartile, men in the lowest T quartile had an odds ratio of 1.47 (95% confidence interval 1.04-2.06) for reporting fair, poor, or very poor health vs excellent or good health. The findings for E1 and calculated free T were similar. In the longitudinal data, the only significant relationship was that between E1 and self-rated health. Compared with those in the highest E1 quartile, those in the lowest quartile experienced deterioration in self-rated health: adjusted odds ratio of 1.84 (95% confidence interval 1.10-3.06). CONCLUSION: Low serum T and E1 are associated with poorer self-rated health in older men, whereas lower serum levels of E1 are predictive of subsequent deterioration in self-rated health over time. Therefore, serum E1 is a novel potential risk factor for poor self-rated health in older men that warrants further investigation.
CONTEXT: Self-rated health and health-related quality of life are inversely associated with increased morbidity and mortality; however, the temporal relationship with reproductive hormones is poorly understood. OBJECTIVES: The objective of the study was to examine relationships between reproductive hormones, self-rated health, and quality of life in older men at baseline as well as changes over a 2-year follow-up. DESIGN, SETTING, AND PARTICIPANTS: One thousand six hundred thirty-seven men aged 70 years and older from the Concord Health and Ageing in Men Project were assessed at baseline and 1316 men returned for the 2-year follow-up. Serum T, dihydrotestosterone, estradiol, and estrone (E1) were measured by liquid chromatography-tandem mass spectrometry and SHBG, LH, and FSH by immunoassay. Logistic regression and multivariate linear regression models were performed. OUTCOME MEASURES: Self-rated health and health-related quality of life measures (12-Item Short Form Health Survey) were determined. RESULTS: In the cross-sectional baseline data, univariate analyses revealed significant associations between many of the hormones and quality-of-life scores and self-rated health. In a multivariable analysis, the associations between T, E1, and calculated free T and self-rated health remained statistically significant. Compared with men in the highest T quartile, men in the lowest T quartile had an odds ratio of 1.47 (95% confidence interval 1.04-2.06) for reporting fair, poor, or very poor health vs excellent or good health. The findings for E1 and calculated free T were similar. In the longitudinal data, the only significant relationship was that between E1 and self-rated health. Compared with those in the highest E1 quartile, those in the lowest quartile experienced deterioration in self-rated health: adjusted odds ratio of 1.84 (95% confidence interval 1.10-3.06). CONCLUSION: Low serum T and E1 are associated with poorer self-rated health in older men, whereas lower serum levels of E1 are predictive of subsequent deterioration in self-rated health over time. Therefore, serum E1 is a novel potential risk factor for poor self-rated health in older men that warrants further investigation.
Authors: R Matthew Coward; Christy Stetter; Allen Kunselman; J C Trussell; Mark C Lindgren; Ruben R Alvero; Peter Casson; Gregory M Christman; Christos Coutifaris; Michael P Diamond; Karl R Hansen; Stephen A Krawetz; Richard S Legro; Randal D Robinson; James F Smith; Anne Z Steiner; Robert A Wild; Heping Zhang; Nanette Santoro Journal: J Urol Date: 2019-07-08 Impact factor: 7.450
Authors: Dean A Tripp; Phylicia Verreault; Steven Tong; Jason Izard; Angela Black; D Robert Siemens Journal: Can Urol Assoc J Date: 2017-10 Impact factor: 1.862
Authors: Guneet Kaur Jasuja; Thomas G Travison; Joanne M Murabito; Maithili N Davda; Adam J Rose; Shehzad Basaria; Andrea Coviello; Ramachandran S Vasan; Ralph D'Agostino; Shalender Bhasin Journal: J Gerontol A Biol Sci Med Sci Date: 2017-08-01 Impact factor: 6.053
Authors: Martin J Connolly; Ngaire Kerse; Tim Wilkinson; Oliver Menzies; Anna Rolleston; Yih Harng Chong; Joanna B Broad; Simon A Moyes; Santosh Jatrana; Ruth Teh Journal: BMJ Open Date: 2017-11-12 Impact factor: 2.692
Authors: Prabin Gyawali; Sean A Martin; Leonie K Heilbronn; Andrew D Vincent; Alicia J Jenkins; Andrzej S Januszewski; Anne W Taylor; Robert J T Adams; Peter D O'Loughlin; Gary A Wittert Journal: PLoS One Date: 2018-07-11 Impact factor: 3.240