Literature DB >> 24551730

Effectiveness of cryogen tetrfluoroethane on elimination of gingival epithelium and its clinical application in gingival depigmentation-histological findings and case series.

Santhosh Kumar1, G Subraya Bhat2, K Mahalinga Bhat3.   

Abstract

OBJECTIVE: To histologically assess and clinically co-relate the effectiveness of cryogen Tetrafluoroethane (TFE) for gingival depigmentation procedure.
MATERIAL AND METHODS: Twelve patients having unaesthetic gingival melanin pigmentation were included in the study. Gingival tissues of eight patients having gingival melanin pigmentation undergoing gingivoplasty or gingivectomy for crownlengthening were exposed to the cryogen and this was used for the histological examination. Gingivectomies were done after 8, 24, 96 hours and after a week of application of tetrafluoroethane. Four fair skinned patients complaining of unaesthetic gingival hyperpigmentation underwent gingival depigmentation using Tetrafluoroethane cryogen.
RESULTS: Histologically after 96 hours of application of cryogen there was complete loss of retepegs and epithelial detachment from the corium was evident. Complete re - epithelialisation was noted after a week and was clinically correlated.
CONCLUSION: We therefore, concluded that histologically tetrafluoroethane can effectively destroy gingival epithelium without causing damage to the connective tissue and clinically the color of the gingiva had more pleasing appearance 6 months postoperatively. Hence the cryogen can be used safely for depigmentation procedure.

Entities:  

Keywords:  Cryosurgery; Depigmentation; Epithelial detachment; Gingiva; Liquid nitrogen; Tetrafluoroethane

Year:  2013        PMID: 24551730      PMCID: PMC3919276          DOI: 10.7860/JCDR/2013/5353.3855

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  14 in total

1.  Cryosurgical treatment of melanin-pigmented gingiva.

Authors:  C J Yeh
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod       Date:  1998-12

2.  Comparative Evaluation of Gingival Depigmentation using Tetrafluoroethane Cryosurgery and Gingival Abrasion Technique: Two Years Follow Up.

Authors:  Santhosh Kumar; G Subraya Bhat; K Mahalinga Bhat
Journal:  J Clin Diagn Res       Date:  2013-02-01

3.  The histological reaction of clinically normal gingiva to freezing.

Authors:  P D Mayers; G Tussing; F M Wentz
Journal:  J Periodontol       Date:  1971-06       Impact factor: 6.993

4.  Cryosurgical treatment of gingival melanin pigmentation with tetrafluoroethane.

Authors:  Fatih Arikan; Ali Gürkan
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod       Date:  2006-11-30

5.  A simple cryosurgical method for treatment of oral mucous cysts.

Authors:  M Toida; J I Ishimaru; N Hobo
Journal:  Int J Oral Maxillofac Surg       Date:  1993-12       Impact factor: 2.789

Review 6.  Cryosurgery updated.

Authors:  E G Kuflik
Journal:  J Am Acad Dermatol       Date:  1994-12       Impact factor: 11.527

7.  Cold testing through full-coverage restorations.

Authors:  Stuart O Miller; James D Johnson; John D Allemang; James M Strother
Journal:  J Endod       Date:  2004-10       Impact factor: 4.171

8.  HFA-134a (1,1,1,2-tetrafluoroethane); lack of oncogenicity in rodents after inhalation.

Authors:  D J Alexander; S E Libretto; H J Chevalier; T Imamura; G Pappritz; J Wilson
Journal:  Hum Exp Toxicol       Date:  1995-09       Impact factor: 2.903

9.  1,1,1,2-Tetrafluoroethane: repeat exposure inhalation toxicity in the rat, developmental toxicity in the rabbit, and genotoxicity in vitro and in vivo.

Authors:  M A Collins; G M Rusch; F Sato; P M Hext; R J Millischer
Journal:  Fundam Appl Toxicol       Date:  1995-05

10.  HFA-134a (1,1,1,2-tetrafluoroethane): effects of inhalation exposure upon reproductive performance, development and maturation of rats.

Authors:  D J Alexander; S E Libretto; M J Adams; E W Hughes; M Bannerman
Journal:  Hum Exp Toxicol       Date:  1996-06       Impact factor: 2.903

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  3 in total

1.  Comparative Evaluation of Gingival Depigmentation by Tetrafluroethane Cryosurgery and Surgical Scalpel Technique. A Randomized Clinical Study.

Authors:  Suraj D Narayankar; Neeraj C Deshpande; Deepak H Dave; Dhaval J Thakkar
Journal:  Contemp Clin Dent       Date:  2017 Jan-Mar

Review 2.  An insight into gingival depigmentation techniques: The pros and cons.

Authors:  Dhafer S Alasmari
Journal:  Int J Health Sci (Qassim)       Date:  2018 Sep-Oct

3.  Efficacy of liquid nitrogen and electrocautery assisted gingival depigmentation in term of patient's perception, histological wound healing - A randomized triple blind clinical trial.

Authors:  Sanjeev Kamboj; Sanjeev Kumar Salaria
Journal:  J Indian Soc Periodontol       Date:  2020-03-02
  3 in total

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