V Parthibane1, N Selvaraj1, V Sathiyapriya1, Zachariah Bobby2, Medha Rajappa3. 1. Ph.D. Student, Department of Biochemistry, JIPMER , Puducherry, India . 2. Additional Professor, Department of Biochemistry, JIPMER , Puducherry, India . 3. Assistant Professor, Department of Biochemistry, JIPMER , Puducherry, India .
Abstract
BACKGROUND: Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of non-enzymatic glycation of proteins and hemoglobin in acute Myocardial Infarction (MI) patients. METHODS: Eighteen acute Myocardial Infarction (MI) patients and 20 healthy controls were enrolled for the present study. Fasting plasma glucose, fructosamine, glycated hemoglobin were evaluated. RESULTS: A significant rise in the mean values of fructosamine and glycated hemoglobin was found in acute myocardial patients when compared with controls. When Pearson's correlation analysis was performed, no significant correlation was found between fasting plasma glucose with either fructosamine or glycated hemoglobin levels. CONCLUSION: This data suggests an increased glycation of both plasma proteins and glycated hemoglobin in acute myocardial patients, which might be independent of prevailing glucose concentration.
BACKGROUND: Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of non-enzymatic glycation of proteins and hemoglobin in acute Myocardial Infarction (MI) patients. METHODS: Eighteen acute Myocardial Infarction (MI) patients and 20 healthy controls were enrolled for the present study. Fasting plasma glucose, fructosamine, glycated hemoglobin were evaluated. RESULTS: A significant rise in the mean values of fructosamine and glycated hemoglobin was found in acute myocardialpatients when compared with controls. When Pearson's correlation analysis was performed, no significant correlation was found between fasting plasma glucose with either fructosamine or glycated hemoglobin levels. CONCLUSION: This data suggests an increased glycation of both plasma proteins and glycated hemoglobin in acute myocardialpatients, which might be independent of prevailing glucose concentration.
Authors: K M Mohan Kumar; Zachariah Bobby; N Selvaraj; Ashok Kumar Das; Bidhan Chandra Koner; S K Sen; R Ramesh; P Ranganathan Journal: Clin Chim Acta Date: 2004-04 Impact factor: 3.786
Authors: Philipp Ehlermann; Kai Eggers; Angelika Bierhaus; Patrick Most; Dieter Weichenhan; Johannes Greten; Peter P Nawroth; Hugo A Katus; Andrew Remppis Journal: Cardiovasc Diabetol Date: 2006-03-30 Impact factor: 9.951