Guadalupe Hernández-Pacheco1, Antonio González-Hermosillo2, Chiharu Murata3, Petra Yescas4, Nilda Espínola-Zavaleta5, Martín Martínez6, Héctor Serrano7. 1. Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico; PhD Program in Biological Sciences and Health, Universidad Autónoma Metropolitana, Mexico. Electronic address: mghp60@yahoo.com. 2. Medical Branch, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico. 3. Department of Methodology, Instituto Nacional de Pediatría, Mexico. 4. Department of Genetics, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico. 5. Department of Echocardiography, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico. 6. Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico. 7. Department of Health Sciences, Universidad Autónoma Metropolitana-Iztapalapa, Mexico.
Abstract
BACKGROUND: Vasovagal syncope is a common clinical condition, consequential to reduced cerebral blood flow resulting from a failure in cardiovascular homeostasis during orthostasis. Blood pressure regulation is the basis for syncope development. In this regulation, the α1a-adrenergic receptor plays a major role. Some studies have found a positive correlation between the Arg347Cys polymorphism of the α1a-adrenergic receptor to hypertension and heart autonomic control. The goal of this study is to evaluate the possible association between the Arg347Cys α1a-adrenergic receptor polymorphism and vasovagal syncope in a Mexican population. METHODS/MAJOR FINDINGS: A sample of 89 vasovagal syncope patients and 40 healthy controls were studied. Arg347Cys α1a-adrenergic receptor polymorphism was determined by the PCR-RFLP method. We found an increased frequency of genotype ArgArg in vasovagal syncope patients. In a logistic regression model significant associations were found in two genetic models, in codominant model (OR=13.21: CI 95% 3.69-54.99, p<0.001) and in additive model (OR=12.68: CI 95% 3.5-53.07, p<0.001) for ArgArg genotype with CysCys as reference. CONCLUSIONS: Our data suggests an important participation of Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope. ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population.
BACKGROUND:Vasovagal syncope is a common clinical condition, consequential to reduced cerebral blood flow resulting from a failure in cardiovascular homeostasis during orthostasis. Blood pressure regulation is the basis for syncope development. In this regulation, the α1a-adrenergic receptor plays a major role. Some studies have found a positive correlation between the Arg347Cys polymorphism of the α1a-adrenergic receptor to hypertension and heart autonomic control. The goal of this study is to evaluate the possible association between the Arg347Cys α1a-adrenergic receptor polymorphism and vasovagal syncope in a Mexican population. METHODS/MAJOR FINDINGS: A sample of 89 vasovagal syncopepatients and 40 healthy controls were studied. Arg347Cys α1a-adrenergic receptor polymorphism was determined by the PCR-RFLP method. We found an increased frequency of genotype ArgArg in vasovagal syncopepatients. In a logistic regression model significant associations were found in two genetic models, in codominant model (OR=13.21: CI 95% 3.69-54.99, p<0.001) and in additive model (OR=12.68: CI 95% 3.5-53.07, p<0.001) for ArgArg genotype with CysCys as reference. CONCLUSIONS: Our data suggests an important participation of Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope. ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population.
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