Farshad Amirkhizi1, Fereydoun Siassi2, Mahmoud Djalali2, Soudabeh Hamedi Shahraki2. 1. Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran. Electronic address:amirkhizi.f@gmail.com. 2. Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
Abstract
OBJECTIVE: The aim of this study was to investigate erythrocyte antioxidant enzyme activities in general and abdominal obese women. METHODS: In this study, 160 women 20-45 years old were randomly selected. General information data were gathered from each sample using questionnaires and face-to-face interviews. Activities of erythrocyte antioxidant enzymes were also evaluated by measuring activities of copper zinc-superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in selected subjects. RESULTS: Mean activity of CuZn-SOD was significantly lower in overweight and obese groups compared to normal weight group (721 ± 81 vs. 987 ± 84, p < 0.01 and 638 ± 74 vs. 987 ± 84, p < 0.001, respectively). Furthermore, both erythrocyte GSH-Px (97.6 ± 45.2 vs. 148.7 ± 54.2, p < 0.01) and CAT (184.2 ± 37.8 vs. 316.7 ± 65.8, p < 0.01) activities was significantly lower in obese women compared to normal weight women. In addition, women with abdominal obesity had lower erythrocyte CuZn-SOD (632 ± 76 vs. 871 ± 84, p < 0.001), GSH-Px (103.6 ± 52.8 vs. 154.7 ± 62.4, p < 0.01) and CAT (216.6 ± 76.4 vs. 298.3 ± 71.1, p < 0.05) activities compared to women with normal body fat distribution. Moreover, multiple linear regression analysis suggests higher prediction of waist circumference (i.e. higher R(2)) on antioxidant enzyme activities in relation to other adiposity indicators. CONCLUSION: Our results provides further evidence suggesting that obesity and, especially, abdominal adiposity associated with decreased antioxidant enzyme activities which in turn, may contribute to oxidative stress related to obesity. Â
OBJECTIVE: The aim of this study was to investigate erythrocyte antioxidant enzyme activities in general and abdominal obesewomen. METHODS: In this study, 160 women 20-45 years old were randomly selected. General information data were gathered from each sample using questionnaires and face-to-face interviews. Activities of erythrocyte antioxidant enzymes were also evaluated by measuring activities of copper zinc-superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in selected subjects. RESULTS: Mean activity of CuZn-SOD was significantly lower in overweight and obese groups compared to normal weight group (721 ± 81 vs. 987 ± 84, p < 0.01 and 638 ± 74 vs. 987 ± 84, p < 0.001, respectively). Furthermore, both erythrocyte GSH-Px (97.6 ± 45.2 vs. 148.7 ± 54.2, p < 0.01) and CAT (184.2 ± 37.8 vs. 316.7 ± 65.8, p < 0.01) activities was significantly lower in obesewomen compared to normal weight women. In addition, women with abdominal obesity had lower erythrocyte CuZn-SOD (632 ± 76 vs. 871 ± 84, p < 0.001), GSH-Px (103.6 ± 52.8 vs. 154.7 ± 62.4, p < 0.01) and CAT (216.6 ± 76.4 vs. 298.3 ± 71.1, p < 0.05) activities compared to women with normal body fat distribution. Moreover, multiple linear regression analysis suggests higher prediction of waist circumference (i.e. higher R(2)) on antioxidant enzyme activities in relation to other adiposity indicators. CONCLUSION: Our results provides further evidence suggesting that obesity and, especially, abdominal adiposity associated with decreased antioxidant enzyme activities which in turn, may contribute to oxidative stress related to obesity. Â
Authors: Xinyu Tang; Todd G Nick; Mario A Cleves; Stephen W Erickson; Ming Li; Jingyun Li; Stewart L MacLeod; Charlotte A Hobbs Journal: PLoS One Date: 2014-10-02 Impact factor: 3.240
Authors: Alexey A Tinkov; Olga P Ajsuvakova; Tommaso Filippini; Ji-Chang Zhou; Xin Gen Lei; Eugenia R Gatiatulina; Bernhard Michalke; Margarita G Skalnaya; Marco Vinceti; Michael Aschner; Anatoly V Skalny Journal: Biomolecules Date: 2020-04-24