Literature DB >> 24548158

Potential therapeutic use of herbal extracts in trypanosomiasis.

Thaise L Teixeira, Samuel Cota Teixeira, Claudio Vieira da Silva, Maria A de Souza.   

Abstract

The aim of the present study was to evaluate the effects of crude extracts from Handroanthus impetiginosa, Ageratum conyzoides, and Ruta graveolens on Leishmania amazonensis and Trypanosoma cruzi infection in vitro. The results showed that the extracts caused significant toxicity in promastigotes and trypomastigotes. A significant decrease in the rate of cell invasion by pretreated trypomastigotes and promastigotes was also observed. The extracts caused a significant reduction of the multiplication of intracellular amastigotes of both parasites. Therefore, these herbal extracts may be potential candidates for the development of drugs for the treatment of leishmaniasis and Chagas disease.

Entities:  

Keywords:  Chagas disease,; Leishmaniasis,; Plant extracts; Treatment,

Mesh：

Substances：

Year:  2013        PMID： 24548158      PMCID： PMC4083165          DOI： 10.1179/2047773213Y.0000000120

Source DB:  PubMed          Journal:  Pathog Glob Health        ISSN： 2047-7724            Impact factor:   2.894


  23 in total

1.  In vitro antileishmanial and antitrypanosomal activities of flavanones from Baccharis retusa DC. (Asteraceae).

Authors:  Simone dos S Grecco; Juliana Q Reimão; André G Tempone; Patricia Sartorelli; Rodrigo L O R Cunha; Paulete Romoff; Marcelo J P Ferreira; Oriana A Fávero; João Henrique G Lago
Journal:  Exp Parasitol       Date:  2011-11-28       Impact factor: 2.011

2.  In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants.

Authors:  Sara Hoet; Frederik Opperdoes; Reto Brun; Victor Adjakidjé; Joëlle Quetin-Leclercq
Journal:  J Ethnopharmacol       Date:  2004-03       Impact factor: 4.360

3.  Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis.

Authors:  C Ferreira; D C Soares; C B Barreto-Junior; M T Nascimento; L Freire-de-Lima; J C Delorenzi; M E F Lima; G C Atella; E Folly; T M U Carvalho; E M Saraiva; L H Pinto-da-Silva
Journal:  Phytochemistry       Date:  2011-08-30       Impact factor: 4.072

4.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

5.  Antimicrobial substances in callus cultures of Ruta graveolens.

Authors:  B Wolters; U Eilert
Journal:  Planta Med       Date:  1981-10       Impact factor: 3.352

6.  Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.

Authors:  L C Green; D A Wagner; J Glogowski; P L Skipper; J S Wishnok; S R Tannenbaum
Journal:  Anal Biochem       Date:  1982-10       Impact factor: 3.365

7.  Antiprotozoal activities of Colombian plants.

Authors:  B Weniger; S Robledo; G J Arango; E Deharo; R Aragón; V Muñoz; J Callapa; A Lobstein; R Anton
Journal:  J Ethnopharmacol       Date:  2001-12       Impact factor: 4.360

Review 8.  American trypanosomiasis (Chagas disease).

Authors:  Anis Rassi; Anis Rassi; Joffre Marcondes de Rezende
Journal:  Infect Dis Clin North Am       Date:  2012-06       Impact factor: 5.982

9.  Anti-leishmanial activity of alkaloidal extracts obtained from different organs of Aspidosperma ramiflorum.

Authors:  Ananda de Castro Cunha; Talita Perez Cantuaria Chierrito; Gerzia Maria de Carvalho Machado; Leonor Laura Pinto Leon; Cleuza Conceição da Silva; Julio Cesar Tanaka; Lauro Mera de Souza; Regina Aparecida Correia Gonçalves; Arildo José Braz de Oliveira
Journal:  Phytomedicine       Date:  2012-02-09       Impact factor: 5.340

10.  IFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strain.

Authors:  Adele A Rodrigues; Jasson S S Saosa; Grace K da Silva; Flávia A Martins; Aline A da Silva; Cecílio P da Silva Souza Neto; Catarina V Horta; Dario S Zamboni; João S da Silva; Eloisa A V Ferro; Claudio V da Silva
Journal:  PLoS Negl Trop Dis       Date:  2012-04-03
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  3 in total

Review 1.  Natural-Product-Based Solutions for Tropical Infectious Diseases.

Authors:  Oyelola Adegboye; Matt A Field; Andreas Kupz; Saparna Pai; Dileep Sharma; Michael J Smout; Phurpa Wangchuk; Yide Wong; Claire Loiseau
Journal:  Clin Microbiol Rev       Date:  2021-09-08       Impact factor: 50.129

Review 2.  Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India.

Authors:  Sujogya Kumar Panda; Walter Luyten
Journal:  Parasite       Date:  2018-03-12       Impact factor: 3.000

3.  Anti-trypanosomal screening of Salvadoran flora.

Authors:  Ulises G Castillo; Ayato Komatsu; Morena L Martínez; Jenny Menjívar; Marvin J Núñez; Yoshinori Uekusa; Yuji Narukawa; Fumiyuki Kiuchi; Junko Nakajima-Shimada
Journal:  J Nat Med       Date:  2021-09-16       Impact factor: 2.343
  3 in total

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