Literature DB >> 2453800

An epitope recognised by inhibitory monoclonal antibodies that react with a 51 kilodalton merozoite surface antigen in Plasmodium falciparum.

R J Epping1, S D Goldstone, L T Ingram, J A Upcroft, R Ramasamy, J A Cooper, G R Bushell, H M Geysen.   

Abstract

Monoclonal antibodies designated 8G10/48 and 9E3/48 raised against mature asexual blood stages of Plasmodium falciparum inhibit parasite growth in vitro. Both antibodies bind to an epitope which includes the linear sequence Ser Thr Asn Ser and which is present in a cDNA clone from a P. falciparum expression library. These antibodies recognise a glycosylated antigen of approximately 51 kDa which is located on the merozoite surface membrane.

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Year:  1988        PMID： 2453800     DOI： 10.1016/0166-6851(88)90173-9

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  30 in total

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Review 3.  Antigenic diversity and immune evasion by malaria parasites.

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4.  Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria.

Authors:  Faith H A Osier; Gregory Fegan; Spencer D Polley; Linda Murungi; Federica Verra; Kevin K A Tetteh; Brett Lowe; Tabitha Mwangi; Peter C Bull; Alan W Thomas; David R Cavanagh; Jana S McBride; David E Lanar; Margaret J Mackinnon; David J Conway; Kevin Marsh
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5.  Structural and antigenic polymorphism of the 35- to 48-kilodalton merozoite surface antigen (MSA-2) of the malaria parasite Plasmodium falciparum.

Authors:  B Fenton; J T Clark; C M Khan; J V Robinson; D Walliker; R Ridley; J G Scaife; J S McBride
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6.  Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design.

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Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

7.  Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2.

Authors:  A Stowers; D Taylor; N Prescott; Q Cheng; J Cooper; A Saul
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8.  Sequence diversity and molecular evolution of the merozoite surface antigen 2 of Plasmodium falciparum.

Authors:  I Felger; V M Marshal; J C Reeder; J A Hunt; C S Mgone; H P Beck
Journal:  J Mol Evol       Date:  1997-08       Impact factor: 2.395

9.  Antibody responses to infections with strains of Plasmodium falciparum expressing diverse forms of merozoite surface protein 2.

Authors:  S Weisman; L Wang; H Billman-Jacobe; D H Nhan; T L Richie; R L Coppel
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10.  Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the immunoglobulin G3 subclass.

Authors:  R R Taylor; D B Smith; V J Robinson; J S McBride; E M Riley
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441
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