Literature DB >> 24536061

Molecular precision chemotherapy: overcoming resistance to targeted therapies?

Stefan Burdach1.   

Abstract

Cytotoxic drugs may have specific effects on oncogenes and their downstream targets. Increase of cancer cell sensitivity due to repression of an oncogene downstream target can be specifically addressed by combined precision chemotherapy, increasing the therapeutic index of chemotherapy and overcoming resistance to highly selective targeted therapies. ©2014 AACR

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24536061     DOI： 10.1158/1078-0432.CCR-13-3194

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  7 in total

1.  Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.

Authors:  Liufeng Mei; Yicheng Chen; Zhimeng Wang; Jian Wang; Jiali Wan; Chunrong Yu; Xin Liu; Wenhua Li
Journal:  Br J Pharmacol       Date:  2015-03-17       Impact factor: 8.739

2.  The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.

Authors:  José Luis Ordóñez; Ana Teresa Amaral; Angel M Carcaboso; David Herrero-Martín; María del Carmen García-Macías; Vicky Sevillano; Diego Alonso; Guillem Pascual-Pasto; Laura San-Segundo; Monica Vila-Ubach; Telmo Rodrigues; Susana Fraile; Cristina Teodosio; Agustín Mayo-Iscar; Miguel Aracil; Carlos María Galmarini; Oscar M Tirado; Jaume Mora; Enrique de Álava
Journal:  Oncotarget       Date:  2015-08-07

3.  Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity.

Authors:  J Herzog; F von Klot-Heydenfeldt; S Jabar; A Ranft; C Rossig; U Dirksen; J Van den Brande; M D'Incalci; I von Luettichau; P J Grohar; W E Berdel; St Burdach
Journal:  Sarcoma       Date:  2016-10-24

Review 4.  Precision medicine in pediatric oncology.

Authors:  Stefan E G Burdach; Mike-Andrew Westhoff; Maximilian Felix Steinhauser; Klaus-Michael Debatin
Journal:  Mol Cell Pediatr       Date:  2018-08-31

Review 5.  Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.

Authors:  Yang Zhang; Yanni Lou; Jingbin Wang; Cunguo Yu; Wenjuan Shen
Journal:  Front Immunol       Date:  2021-01-21       Impact factor: 7.561

6.  A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia.

Authors:  L Mannarino; L Paracchini; I Craparotta; M Romano; S Marchini; R Gatta; E Erba; L Clivio; C Romualdi; M D'Incalci; L Beltrame; L Pattini
Journal:  Pharmacogenomics J       Date:  2016-12-13       Impact factor: 3.550

7.  Transcriptome based individualized therapy of refractory pediatric sarcomas: feasibility, tolerability and efficacy.

Authors:  Bushra Weidenbusch; Günther H S Richter; Marie Sophie Kesper; Monika Guggemoos; Katja Gall; Carolin Prexler; Ilya Kazantsev; Alexandra Sipol; Lars Lindner; Michaela Nathrath; Olaf Witt; Katja Specht; Frigga Beitinger; Carolin Knebel; Stuart Hosie; Rüdiger von Eisenhardt-Rothe; Wilko Weichert; Irene Teichert-von Luettichau; Stefan Burdach
Journal:  Oncotarget       Date:  2018-04-17
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.