| Literature DB >> 24535942 |
Hana Cho1, Yong-Yeon Cho, You Han Bae, Han Chang Kang.
Abstract
Nontoxic endogenous nucleotides such as adenosine triphosphate and guanosine triphosphate have secondary phosphate groups, causing proton-buffering capacity and/or hemolytic activity in endolysosomal pH ranges. Nucleotides co-delivered in single polymeric pDNA nanocarrier induce highly enhanced transfection efficiency with negligible cytotoxicity due to their endosomolytic functions.Entities:
Keywords: ATP; drug delivery; endosomolytic material; gene delivery; nucleotide
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Year: 2014 PMID： 24535942 DOI： 10.1002/adhm.201400008
Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933