Wagner Gomes da Silva1, Teresa Cristina Ribeiro Bartholomeu Dos Santos2, Márcia Grillo Cabral3, Rebeca Souza Azevedo4, Fábio Ramôa Pires5. 1. Oral Pathology, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. 2. Professor, Oral Pathology, State University of Rio de Janeiro; Oral Pathology, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil. 3. Professor, Oral Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. 4. Professor, Oral Pathology, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil. 5. Professor, Oral Pathology, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: ramoafop@yahoo.com.
Abstract
OBJECTIVE: Benign and malignant tumor cells can express altered adhesion properties, and these features can be associated with their proliferative and invasive characteristics. This study aimed to evaluate syndecan-1 and Ki-67 expression in ghost cell-containing odontogenic tumors. STUDY DESIGN: Clinical data were retrieved from laboratory records, and hematoxylin-eosin-stained slides and sections, labeled with monoclonal antibodies anti-syndecan-1 and anti-Ki-67 using the immunoperoxidase technique, were evaluated. RESULTS: Included were 21 central calcifying cystic odontogenic tumors (CCOTs) (4 associated with odontoma), 2 peripheral CCOTs, 1 dentinogenic ghost cell tumor, and 1 ghost cell odontogenic carcinoma (GCOC). Syndecan-1 was mainly expressed in cells resembling stellate reticulum and in stromal cells from the fibrous capsule. The mean Ki-67 labeling index was 4.1% (49.3% for GCOC), but it was not associated with syndecan-1 expression. CONCLUSIONS: Syndecan-1 is variably expressed in cells resembling the stellate reticulum, stromal cells, and basal cells and might be associated with the biology of these tumors.
OBJECTIVE: Benign and malignant tumor cells can express altered adhesion properties, and these features can be associated with their proliferative and invasive characteristics. This study aimed to evaluate syndecan-1 and Ki-67 expression in ghost cell-containing odontogenic tumors. STUDY DESIGN: Clinical data were retrieved from laboratory records, and hematoxylin-eosin-stained slides and sections, labeled with monoclonal antibodies anti-syndecan-1 and anti-Ki-67 using the immunoperoxidase technique, were evaluated. RESULTS: Included were 21 central calcifying cystic odontogenic tumors (CCOTs) (4 associated with odontoma), 2 peripheral CCOTs, 1 dentinogenic ghost cell tumor, and 1 ghost cell odontogenic carcinoma (GCOC). Syndecan-1 was mainly expressed in cells resembling stellate reticulum and in stromal cells from the fibrous capsule. The mean Ki-67 labeling index was 4.1% (49.3% for GCOC), but it was not associated with syndecan-1 expression. CONCLUSIONS:Syndecan-1 is variably expressed in cells resembling the stellate reticulum, stromal cells, and basal cells and might be associated with the biology of these tumors.