Annapaola Prestia1, Enrica Cavedo2, Marina Boccardi1, Cristina Muscio1, Andrea Adorni3, Cristina Geroldi4, Matteo Bonetti5, Paul M Thompson6, Giovanni B Frisoni7. 1. LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy. 2. LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy; Cognition, Neuroimaging, and Brain Diseases Laboratory, Centre de Recherche de l'Institut du Cerveau et de la Moelle Épinière (CRICM-UMRS 975), Université Pierre et Marie Curie-Paris 6, France. 3. Psychogeriatric Ward - IRCCS San Giovanni di Dio-FBF, Brescia, Italy. 4. LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy; Psychogeriatric Ward - IRCCS San Giovanni di Dio-FBF, Brescia, Italy. 5. Service of Neuroradiology, Istituto Clinico Citta' di Brescia, Brescia, Italy. 6. Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. 7. LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni di Dio-FBF, Brescia, Italy; Memory Clinic and Laboratoire de Neuroimagerie du Vieillissement (LANVIE), University Hospitals and University of Geneva, Geneva, CH. Electronic address: gfrisoni@fatebenefratelli.it.
Abstract
OBJECTIVES: Morphological abnormalities have been reported for the hippocampi and amygdalae in young schizophrenia patients, but very little is known about the pattern of abnormalities in elderly schizophrenia patients. Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophrenia patients compared with healthy elderly subjects. We also related these differences to clinical symptom severity. DESIGN: 20 schizophrenia patients (mean age: 67.4 ± 6.2 years; Mini-Mental State Exam: 22.8 ± 4.4) and 20 healthy elderly subjects (70.3 ± 7.5 years; 29.0 ± 1.1) underwent high resolution magnetic resonance imaging of the brain. The Radial Atrophy Mapping technique was used to reconstruct the 3D shape of the amygdala and the hippocampus. Local differences in tissue reductions were computed between groups and permutation tests were run to correct for multiple comparisons, in statistical maps thresholded at p = 0.05. RESULTS: Significant tissue reduction was observed bilaterally in the amygdala and hippocampus of schizophrenia patients. The basolateral-ventral-medial amygdalar nucleus showed the greatest involvement, with over 30% local tissue reduction. The centro-medial, cortical, and lateral nuclei were also atrophic in patients. The hippocampus showed significant tissue loss in the medio-caudal and antero-lateral aspects of CA1, and in medial section of its left head (pre- and para-subiculum). In the left amygdala and hippocampus, local tissue volumes were significantly correlated with negative symptoms. CONCLUSIONS: Tissue loss and altered morphology were found in elderly schizophrenia patients. Tissue loss mapped to amygdalo-hippocampal subregions known to have bidirectional and specific connections with frontal cortical and limbic structures and was related to clinical severity.
OBJECTIVES: Morphological abnormalities have been reported for the hippocampi and amygdalae in young schizophreniapatients, but very little is known about the pattern of abnormalities in elderly schizophreniapatients. Here we investigated local structural differences in the hippocampi and amygdalae of elderly schizophreniapatients compared with healthy elderly subjects. We also related these differences to clinical symptom severity. DESIGN: 20 schizophreniapatients (mean age: 67.4 ± 6.2 years; Mini-Mental State Exam: 22.8 ± 4.4) and 20 healthy elderly subjects (70.3 ± 7.5 years; 29.0 ± 1.1) underwent high resolution magnetic resonance imaging of the brain. The Radial Atrophy Mapping technique was used to reconstruct the 3D shape of the amygdala and the hippocampus. Local differences in tissue reductions were computed between groups and permutation tests were run to correct for multiple comparisons, in statistical maps thresholded at p = 0.05. RESULTS: Significant tissue reduction was observed bilaterally in the amygdala and hippocampus of schizophreniapatients. The basolateral-ventral-medial amygdalar nucleus showed the greatest involvement, with over 30% local tissue reduction. The centro-medial, cortical, and lateral nuclei were also atrophic in patients. The hippocampus showed significant tissue loss in the medio-caudal and antero-lateral aspects of CA1, and in medial section of its left head (pre- and para-subiculum). In the left amygdala and hippocampus, local tissue volumes were significantly correlated with negative symptoms. CONCLUSIONS: Tissue loss and altered morphology were found in elderly schizophreniapatients. Tissue loss mapped to amygdalo-hippocampal subregions known to have bidirectional and specific connections with frontal cortical and limbic structures and was related to clinical severity.
Authors: Tom F Nugent; David H Herman; Anna Ordonez; Deanna Greenstein; Kiralee M Hayashi; Marge Lenane; Liv Clasen; David Jung; Arthur W Toga; Jay N Giedd; Judith L Rapoport; Paul M Thompson; Nitin Gogtay Journal: Schizophr Res Date: 2006-12-11 Impact factor: 4.939
Authors: Francine M Benes; Benjamin Lim; David Matzilevich; Sivan Subburaju; John P Walsh Journal: Proc Natl Acad Sci U S A Date: 2008-12-22 Impact factor: 11.205
Authors: Lei Wang; Daniel Mamah; Michael P Harms; Meghana Karnik; Joseph L Price; Mokhtar H Gado; Paul A Thompson; Deanna M Barch; Michael I Miller; John G Csernansky Journal: Biol Psychiatry Date: 2008-09-23 Impact factor: 13.382
Authors: Andrew J Plassard; Shunxing Bao; Maureen McHugo; Lori Beason-Held; Jennifer U Blackford; Stephan Heckers; Bennett A Landman Journal: Magn Reson Imaging Date: 2021-04-24 Impact factor: 3.130