F le Grange1, A M Cassoni2, B M Seddon3. 1. University College London Hospitals NHS Foundation Trust, Department of Oncology, 1st Floor Central, 250 Euston Road, London NW1 2PG, UK. Electronic address: franel.legrange@uclh.nhs.uk. 2. University College London Hospitals NHS Foundation Trust, Department of Oncology, 1st Floor Central, 250 Euston Road, London NW1 2PG, UK. 3. University College London Hospitals NHS Foundation Trust, Department of Oncology, 1st Floor Central, 250 Euston Road, London NW1 2PG, UK; NIHR University College London Hospitals Biomedical Research Centre, 1st Floor Maple House, Suite A, 149 Tottenham Court Road, London W1T 7DN, UK.
Abstract
AIMS: To evaluate tumour volume changes after preoperative radiotherapy (PRT) for borderline operable soft tissue sarcomas (STS). MATERIALS AND METHODS: A retrospective review was performed of 68 patients who received PRT between December 2004 and July 2011. Endpoints were radiological response, surgical margins, local control and survival. RESULTS: Median tumour size was 12.5 cm. Tumour location was extremity (87%), trunk (12%), and neck (1%). Commonest histological subtypes were myxoid liposarcoma (32%) and myxofibrosarcoma (16%). The majority of patients (88%) received 50 Gy in 25 fractions. Post-radiotherapy imaging was available in 55 cases. By RECIST there was stable disease in 89%, partial response in 7% and progressive disease in 4%. Tumour volumes reduced in 80%. Median change in maximal tumour dimension was -13.6%; median change in volume was greater, at -33.3%. Tumour volumes increased in 11 cases (20%). However, surgical margins were clear in all 11 cases, with no local recurrences in this group. For the entire group, surgical margins were clear in 93%, and microscopically positive in 7%. Eight patients (12%) had local relapse at 2-24.8 months after surgery. Two year local relapse free survival was 87.5%; 2 year overall survival was 74.7%. CONCLUSION: The majority of tumours showed reduction in volume. A small number of tumours increased in volume, but there was no definite relationship between volume increase and poor surgical outcomes or lower local control rates. Local control was equivalent to published series' of PRT. PRT is a reasonable approach in patients with borderline resectable tumours.
AIMS: To evaluate tumour volume changes after preoperative radiotherapy (PRT) for borderline operable soft tissue sarcomas (STS). MATERIALS AND METHODS: A retrospective review was performed of 68 patients who received PRT between December 2004 and July 2011. Endpoints were radiological response, surgical margins, local control and survival. RESULTS: Median tumour size was 12.5 cm. Tumour location was extremity (87%), trunk (12%), and neck (1%). Commonest histological subtypes were myxoid liposarcoma (32%) and myxofibrosarcoma (16%). The majority of patients (88%) received 50 Gy in 25 fractions. Post-radiotherapy imaging was available in 55 cases. By RECIST there was stable disease in 89%, partial response in 7% and progressive disease in 4%. Tumour volumes reduced in 80%. Median change in maximal tumour dimension was -13.6%; median change in volume was greater, at -33.3%. Tumour volumes increased in 11 cases (20%). However, surgical margins were clear in all 11 cases, with no local recurrences in this group. For the entire group, surgical margins were clear in 93%, and microscopically positive in 7%. Eight patients (12%) had local relapse at 2-24.8 months after surgery. Two year local relapse free survival was 87.5%; 2 year overall survival was 74.7%. CONCLUSION: The majority of tumours showed reduction in volume. A small number of tumours increased in volume, but there was no definite relationship between volume increase and poor surgical outcomes or lower local control rates. Local control was equivalent to published series' of PRT. PRT is a reasonable approach in patients with borderline resectable tumours.
Authors: Theodoros Soldatos; Shivani Ahlawat; Elizabeth Montgomery; Majid Chalian; Michael A Jacobs; Laura M Fayad Journal: Radiology Date: 2015-09-21 Impact factor: 11.105
Authors: Christian Isaac; John Kavanagh; Anthony Michael Griffin; Colleen I Dickie; Rakesh Mohankumar; Peter W Chung; Charles N Catton; David Shultz; Peter C Ferguson; Jay S Wunder Journal: Br J Radiol Date: 2021-12-03 Impact factor: 3.039
Authors: Ramiz Abu-Hijlih; Sara Mheid; Fawzi Abuhijla; Wafa Asha; Issa Mohamad; Abdullah Alrashdan; Samer Alheet; Haitham Kana'an; Mohammad Abd Al-Raheem; Abdelatif Almousa Journal: Rep Pract Oncol Radiother Date: 2019-03-18