Human Mousavi Fatemi1, Biljana Popovic-Todorovic2, Peter Humaidan3, Shahar Kol4, Manish Banker5, Paul Devroey6, Juan Antonio García-Velasco7. 1. Center for Reproductive Medicine, Dutch-Speaking Free University Brussels, Brussels, Belgium. Electronic address: Human.MousaviFatemi@uzbrussel.be. 2. Special Gynecology Hospital "Ivanovic", Belgrade, Serbia. 3. Fertility Clinic, Skive Regional Hospital and Faculty of Health, Aarhus University, Aarhus, Denmark. 4. Department of Obstetrics and Gynecology, IVF Unit, Rambam Medical Center, Haifa, Israel. 5. NOVAIVI, Ahmadabad, India. 6. Center for Reproductive Medicine, Dutch-Speaking Free University Brussels, Brussels, Belgium. 7. Instituto Valenciano de Infertilidad-MADRID, Madrid, Spain.
Abstract
OBJECTIVE: To report two cases with GnRH agonist triggering and a freeze-all approach in a GnRH antagonist protocol resulting in the development of severe ovarian hyperstimulation syndrome (OHSS), requiring hospitalization and peritoneal drainage. DESIGN: Two case reports. SETTING: A tertiary referral center and an obstetrics and gynecology department of a hospital. PATIENT(S): Case 1 and case 2: severe OHSS with abdominal distension, ascites development, and hemoconcentration. INTERVENTION(S): Case 1 and case 2: diagnosed by clinical, hematologic, and ultrasound findings. Hospitalization, IV infusion, and peritoneal drainage. MAIN OUTCOME MEASURE(S): Symptomatic treatment and prevention of further complication. RESULT(S): Complete recovery. CONCLUSION(S): Two cases of severe OHSS after GnRH agonist trigger in a GnRH antagonist protocol without the administration of any hCG for luteal-phase support. Clinicians have to be aware that even the sequential approach to ovarian stimulation with a freeze-all attitude does not completely eliminate OHSS in all patients.
OBJECTIVE: To report two cases with GnRH agonist triggering and a freeze-all approach in a GnRH antagonist protocol resulting in the development of severe ovarian hyperstimulation syndrome (OHSS), requiring hospitalization and peritoneal drainage. DESIGN: Two case reports. SETTING: A tertiary referral center and an obstetrics and gynecology department of a hospital. PATIENT(S): Case 1 and case 2: severe OHSS with abdominal distension, ascites development, and hemoconcentration. INTERVENTION(S): Case 1 and case 2: diagnosed by clinical, hematologic, and ultrasound findings. Hospitalization, IV infusion, and peritoneal drainage. MAIN OUTCOME MEASURE(S): Symptomatic treatment and prevention of further complication. RESULT(S): Complete recovery. CONCLUSION(S): Two cases of severe OHSS after GnRH agonist trigger in a GnRH antagonist protocol without the administration of any hCG for luteal-phase support. Clinicians have to be aware that even the sequential approach to ovarian stimulation with a freeze-all attitude does not completely eliminate OHSS in all patients.
Authors: Talya Shaulov; Maria P Vélez; Karen Buzaglo; Simon J Phillips; Isaac Jacques Kadoch Journal: J Assist Reprod Genet Date: 2015-06-04 Impact factor: 3.412
Authors: Katrien Stouffs; Sari Daelemans; Samuel Santos-Ribeiro; Sara Seneca; Alexander Gheldof; Ali Sami Gürbüz; Michel De Vos; Herman Tournaye; Christophe Blockeel Journal: J Assist Reprod Genet Date: 2018-11-27 Impact factor: 3.412