Literature DB >> 24534272

CFTR structure and cystic fibrosis.

Natasha Cant1, Naomi Pollock1, Robert C Ford2.   

Abstract

CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-binding cassette family of membrane proteins. Although almost all members of this family are transporters, CFTR functions as a channel with specificity for anions, in particular chloride and bicarbonate. In this review we look at what is known about CFTR structure and function within the context of the ATP-binding cassette family. We also review current strategies aimed at obtaining the high resolution structure of the protein.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CFTR; Cystic fibrosis; Ion channel; Membrane protein; Protein structure

Mesh：

Substances：

Year:  2014        PMID： 24534272     DOI： 10.1016/j.biocel.2014.02.004

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  25 in total

1.  Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells.

Authors:  Vina Z Zinn; Aditi Khatri; Maija I Mednieks; Arthur R Hand
Journal:  Eur J Oral Sci       Date:  2015-04-22       Impact factor: 2.612

2.  PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics.

Authors:  Alison E Fohner; Ellen M McDonagh; John P Clancy; Michelle Whirl Carrillo; Russ B Altman; Teri E Klein
Journal:  Pharmacogenet Genomics       Date:  2017-01       Impact factor: 2.089

3.  A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR).

Authors:  Ellen Hildebrandt; Qinghai Zhang; Natasha Cant; Haitao Ding; Qun Dai; Lingling Peng; Yu Fu; Lawrence J DeLucas; Robert Ford; John C Kappes; Ina L Urbatsch
Journal:  Biochim Biophys Acta       Date:  2014-07-24

4.  Buried chloride stereochemistry in the Protein Data Bank.

Authors:  Oliviero Carugo
Journal:  BMC Struct Biol       Date:  2014-09-23

5.  Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore.

Authors:  Yassine El Hiani; Paul Linsdell
Journal:  J Biol Chem       Date:  2015-05-05       Impact factor: 5.157

6.  A stable human-cell system overexpressing cystic fibrosis transmembrane conductance regulator recombinant protein at the cell surface.

Authors:  Ellen Hildebrandt; Alok Mulky; Haitao Ding; Qun Dai; Andrei A Aleksandrov; Bekim Bajrami; Pamela Ann Diego; Xing Wu; Marjorie Ray; Anjaparavanda P Naren; John R Riordan; Xudong Yao; Lawrence J DeLucas; Ina L Urbatsch; John C Kappes
Journal:  Mol Biotechnol       Date:  2015-05       Impact factor: 2.695

Review 7.  Molecular modelling and molecular dynamics of CFTR.

Authors:  Isabelle Callebaut; Brice Hoffmann; Pierre Lehn; Jean-Paul Mornon
Journal:  Cell Mol Life Sci       Date:  2016-10-07       Impact factor: 9.261

8.  Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase.

Authors:  Pengchao Hao; Jian Xia; Jie Liu; Martin Di Donato; Konrad Pakula; Aurélien Bailly; Michal Jasinski; Markus Geisler
Journal:  J Biol Chem       Date:  2020-07-22       Impact factor: 5.157

9.  Substitution of Yor1p NBD1 residues improves the thermal stability of Human Cystic Fibrosis Transmembrane Conductance Regulator.

Authors:  B M Xavier; E Hildebrandt; F Jiang; H Ding; J C Kappes; I L Urbatsch
Journal:  Protein Eng Des Sel       Date:  2017-10-01       Impact factor: 1.650

Review 10.  Intracellular pH in sperm physiology.

Authors:  Takuya Nishigaki; Omar José; Ana Laura González-Cota; Francisco Romero; Claudia L Treviño; Alberto Darszon
Journal:  Biochem Biophys Res Commun       Date:  2014-06-02       Impact factor: 3.575
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