L Maillet1, R C Rudigoz2, R Buffin3, J Massardier4, P Gaucherand4, C Huissoud5. 1. Service de gynécologie-obstétrique, hospices civils de Lyon, hôpital de la Croix-Rousse, 104, grande rue de la Croix-Rousse, 69004 Lyon cedex 04, France. Electronic address: laurinemaillet@gmail.com. 2. Service de gynécologie-obstétrique, hospices civils de Lyon, hôpital de la Croix-Rousse, 104, grande rue de la Croix-Rousse, 69004 Lyon cedex 04, France; Université Claude-Bernard - Lyon 1, 8, avenue Rockefeller, 69373 Lyon cedex 08, France. 3. Service de gynécologie-obstétrique, hospices civils de Lyon, hôpital de la Croix-Rousse, 104, grande rue de la Croix-Rousse, 69004 Lyon cedex 04, France. 4. Service de gynécologie-obstétrique, hospices civils de Lyon, hôpital Femme-Mère-Enfants, 59, boulevard Pinel, 69500 Bron, France. 5. Service de gynécologie-obstétrique, hospices civils de Lyon, hôpital de la Croix-Rousse, 104, grande rue de la Croix-Rousse, 69004 Lyon cedex 04, France; Inserm U846, Stem Cell and Brain Research Institute, 18, avenue Doyen-Lepine, 69500 Bron, France; UMR-S 846, université Lyon 1, 69003 Lyon, France.
Abstract
OBJECTIVE: Echogenic bowel (EB) represents 1 % of pregnancy and is a risk factor of fetal pathology (infection, cystic fibrosis, aneuploidy). The aim of our study was to determine the fetuses' outcomes with isolated EB. PATIENTS AND METHODS: This is a retrospective study of all patients who presented singleton gestations with a fetal isolated echogenic bowel between 2004 and 2011 in two prenatal diagnosis centers. Search of aneuploidy, infection and cystic fibrosis was systematically proposed as well as an ultrasound monitoring. RESULTS: On 109 fetus addressed for isolate echogenic bowel five had other signs associated and 74 had a real isolated echogenic bowel (without dilatation, calcification, intrauterine growth restriction). In 30 cases, the EB was not found. Eighty-five percent of the patients had in the first trimester a screening for trisomy 21. None fetus with isolated EB had trisomy, infection or cystic fibrosis. One fetus died in utero and one newborn died of a metabolic disease without digestive repercussions. DISCUSSION AND CONCLUSION: The risk of trisomy 21 and the risk to have a serious disease appear low for the fetus with EB. It does not seem necessary to propose a systematic amniocentesis in case of isolated echogenic bowel.
OBJECTIVE:Echogenic bowel (EB) represents 1 % of pregnancy and is a risk factor of fetal pathology (infection, cystic fibrosis, aneuploidy). The aim of our study was to determine the fetuses' outcomes with isolated EB. PATIENTS AND METHODS: This is a retrospective study of all patients who presented singleton gestations with a fetal isolated echogenic bowel between 2004 and 2011 in two prenatal diagnosis centers. Search of aneuploidy, infection and cystic fibrosis was systematically proposed as well as an ultrasound monitoring. RESULTS: On 109 fetus addressed for isolate echogenic bowel five had other signs associated and 74 had a real isolated echogenic bowel (without dilatation, calcification, intrauterine growth restriction). In 30 cases, the EB was not found. Eighty-five percent of the patients had in the first trimester a screening for trisomy 21. None fetus with isolated EB had trisomy, infection or cystic fibrosis. One fetus died in utero and one newborn died of a metabolic disease without digestive repercussions. DISCUSSION AND CONCLUSION: The risk of trisomy 21 and the risk to have a serious disease appear low for the fetus with EB. It does not seem necessary to propose a systematic amniocentesis in case of isolated echogenic bowel.