Literature DB >> 24533289

Global analysis of Plasmodium falciparum Na(+)/H(+) exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine.

Didier Ménard1, Valérie Andriantsoanirina2, Nimol Khim1, Arsène Ratsimbasoa3, Benoit Witkowski1, Christophe Benedet1, Lydie Canier1, Odile Mercereau-Puijalon4, Rémy Durand2.   

Abstract

The aim of this study was to provide a comprehensive analysis of the worldwide genetic polymorphism of ms4760 alleles of the pfnhe-1 gene and to discuss their usefulness as molecular marker of quinine resistance (QNR). A new numbering of ms4760 allele, classification grouping ms4760 alleles according to the number of DNNND and DDNHNDNHNND repeat motifs in blocks II and V was also proposed. A total of 1508 ms4760 sequences from isolates, culture-adapted parasites or reference strains from various geographical regions were retrieved from GenBank (last update on 15th June 2012) or from publications and were used for genetic analyses. The association of different alleles of pfnhe-1 with resistance to quinoline antimalarial drugs showed marked geographic disparities. The validity and reliability of candidate polymorphisms in pfnhe-1 gene as molecular markers of QNR appeared restricted to endemic areas from South Asia or possibly East African countries and needs to be confirmed.

Entities:  

Keywords:  Genetic polymorphism; Malaria; Na+/H+ exchanger; Plasmodium falciparum; Quinine resistance

Year:  2012        PMID： 24533289      PMCID： PMC3862431          DOI： 10.1016/j.ijpddr.2012.10.001

Source DB:  PubMed          Journal:  Int J Parasitol Drugs Drug Resist        ISSN： 2211-3207            Impact factor:   4.077


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