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Literature DB >> 24533279

Worming our way closer to the clinic.

Abstract

In a recent issue of "The International Journal for Parasitology: Drugs and Drug Resistance" Prof. David Pritchard from the University of Nottingham offers his intriguing opinion on the current status of "worm therapy" and outlines future research priorities aimed at bringing this research area closer to the clinic. In this response article we discuss various aspects of the current state of the research field and offer some alternative viewpoints regarding the future of "worm therapy".

Keywords: Allergy; Autoimmunity; Helminth; Worm therapy

Year: 2012 PMID： 24533279 PMCID： PMC3862412 DOI： 10.1016/j.ijpddr.2012.07.001

Source DB: PubMed Journal: Int J Parasitol Drugs Drug Resist ISSN： 2211-3207 Impact factor: 4.077

31 in total

1. Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes.

Authors: James P Hewitson; Kara J Filbey; John R Grainger; Adam A Dowle; Mark Pearson; Janice Murray; Yvonne Harcus; Rick M Maizels
Journal: J Immunol Date: 2011-09-30 Impact factor: 5.422

2. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial.

Authors: Robert W Summers; David E Elliott; Joseph F Urban; Robin A Thompson; Joel V Weinstock
Journal: Gastroenterology Date: 2005-04 Impact factor: 22.682

3. Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis.

Authors: Robert W Li; Sitao Wu; Weizhong Li; Karl Navarro; Robin D Couch; Dolores Hill; Joseph F Urban
Journal: Infect Immun Date: 2012-04-09 Impact factor: 3.441

4. Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes.

Authors: Alirio J Melendez; Margaret M Harnett; Peter N Pushparaj; W S Fred Wong; Hwee Kee Tay; Charles P McSharry; William Harnett
Journal: Nat Med Date: 2007-10-21 Impact factor: 53.440

5. Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren.

Authors: Anita H J van den Biggelaar; Laura C Rodrigues; Ronald van Ree; Jaring S van der Zee; Yvonne C M Hoeksma-Kruize; John H M Souverijn; Michel A Missinou; Steffen Borrmann; Peter G Kremsner; Maria Yazdanbakhsh
Journal: J Infect Dis Date: 2004-02-18 Impact factor: 5.226

6. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.

Authors: John R Grainger; Katie A Smith; James P Hewitson; Henry J McSorley; Yvonne Harcus; Kara J Filbey; Constance A M Finney; Edward J D Greenwood; David P Knox; Mark S Wilson; Yasmine Belkaid; Alexander Y Rudensky; Rick M Maizels
Journal: J Exp Med Date: 2010-09-27 Impact factor: 14.307

7. Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam.

Authors: C Flohr; L N Tuyen; R J Quinnell; S Lewis; T T Minh; J Campbell; C Simmons; G Telford; A Brown; T T Hien; J Farrar; H Williams; D I Pritchard; J Britton
Journal: Clin Exp Allergy Date: 2009-09-15 Impact factor: 5.018

8. Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression.

Authors: Mariela Segura; Zhong Su; Ciriaco Piccirillo; Mary M Stevenson
Journal: Eur J Immunol Date: 2007-07 Impact factor: 5.532