Literature DB >> 24533277

Is paromomycin the drug of choice for eradication of Dientamoeba fragilis in adults?

Jaap J van Hellemond1, Nicky Molhoek2, Rob Koelewijn3, Pieter J Wismans2, Perry J J van Genderen2.   

Abstract

Dientamoeba fragilis is a debated protozoan parasite that is often detected in stools of patients with chronic gastro-intestinal complaints. A retrospective follow-up study of a large cohort of patients was performed to better understand the natural course of the infection and possible treatment options. D. fragilis was spontaneously cleared in 41% of untreated cases. With an eradication rate of 98%, treatment with paromomycin appeared more effective than treatment with clioquinol (83%) or metronidazole (57%).

Entities:  

Keywords:  Diarrhea; Dientamoeba fragilis; Metronidazole; Parasite

Year:  2012        PMID： 24533277      PMCID： PMC3862430          DOI： 10.1016/j.ijpddr.2012.03.002

Source DB:  PubMed          Journal:  Int J Parasitol Drugs Drug Resist        ISSN： 2211-3207            Impact factor:   4.077


  17 in total

Review 1.  A review of Dientamoeba fragilis carriage in humans: several reasons why this organism should be considered in the diagnosis of gastrointestinal illness.

Authors:  Joel L N Barratt; John Harkness; Deborah Marriott; John T Ellis; Damien Stark
Journal:  Gut Microbes       Date:  2011 Jan-Feb

2.  Triple Faeces Test: an effective tool for detection of intestinal parasites in routine clinical practice.

Authors:  T van Gool; R Weijts; E Lommerse; T G Mank
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-05-08       Impact factor: 3.267

3.  A review of the clinical presentation of dientamoebiasis.

Authors:  Damien Stark; Joel Barratt; Tamalee Roberts; Deborah Marriott; John Harkness; John Ellis
Journal:  Am J Trop Med Hyg       Date:  2010-04       Impact factor: 2.345

4.  Treatment of Dientamoeba fragilis infection with paromomycin.

Authors:  Olivier Vandenberg; Hichem Souayah; Françoise Mouchet; Anne Dediste; Tom van Gool
Journal:  Pediatr Infect Dis J       Date:  2007-01       Impact factor: 2.129

5.  Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole.

Authors:  N Girginkardeşler; S Coşkun; I Cüneyt Balcioğlu; P Ertan; U Z Ok
Journal:  Clin Microbiol Infect       Date:  2003-02       Impact factor: 8.067

6.  A case-controlled study of Dientamoeba fragilis infections in children.

Authors:  G R Banik; J L N Barratt; D Marriott; J Harkness; J T Ellis; D Stark
Journal:  Parasitology       Date:  2011-04-27       Impact factor: 3.234

7.  The prevalence of Dientamoeba fragilis in patients with suspected enteroparasitic disease in a metropolitan area in Denmark.

Authors:  C R Stensvold; M C Arendrup; K Mølbak; H V Nielsen
Journal:  Clin Microbiol Infect       Date:  2007-08       Impact factor: 8.067

8.  Clinical and microbiological features of dientamoebiasis in patients suspected of suffering from a parasitic gastrointestinal illness: a comparison of Dientamoeba fragilis and Giardia lamblia infections.

Authors:  Olivier Vandenberg; Ron Peek; Hichem Souayah; Anne Dediste; Michel Buset; Robert Scheen; Patricia Retore; Georges Zissis; Tom van Gool
Journal:  Int J Infect Dis       Date:  2006-02-15       Impact factor: 3.623

9.  A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.

Authors:  O Kurt; N Girginkardeşler; I C Balcioğlu; A Ozbilgin; U Z Ok
Journal:  Clin Microbiol Infect       Date:  2008-04-05       Impact factor: 8.067

10.  Dientamoeba fragilis: a gastrointestinal protozoan infection in adults.

Authors:  M J Spencer; M R Chapin; L S Garcia
Journal:  Am J Gastroenterol       Date:  1982-08       Impact factor: 10.864
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  6 in total

Review 1.  Does Dientamoeba fragilis cause diarrhea? A systematic review.

Authors:  Zing-Wae Wong; Kate Faulder; Joan L Robinson
Journal:  Parasitol Res       Date:  2018-02-05       Impact factor: 2.289

Review 2.  Understanding drug resistance in human intestinal protozoa.

Authors:  Hend Aly El-Taweel
Journal:  Parasitol Res       Date:  2015-03-19       Impact factor: 2.289

Review 3.  Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel.

Authors:  Damien Stark; Joel Barratt; Douglas Chan; John T Ellis
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

Review 4.  Current treatment options for Dientamoeba fragilis infections.

Authors:  Noriyuki Nagata; Deborah Marriott; John Harkness; John T Ellis; Damien Stark
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2012-09-03       Impact factor: 4.077

5.  Two-day enema antibiotic therapy for parasite eradication and resolution of symptoms.

Authors:  Niloufar Roshan; Annabel Clancy; Anoja W Gunaratne; Antoinette LeBusque; Denise Pilarinos; Thomas J Borody
Journal:  World J Gastroenterol       Date:  2020-07-14       Impact factor: 5.742

6.  Paromomycin is superior to metronidazole in Dientamoeba fragilis treatment.

Authors:  Ander Burgaña; Rosa Abellana; Stanislav Zlatanov Yordanov; Rabee Kazan; A Mauricio Pérez Ortiz; Cristina Castillo Ramos; Christian Garavito Hernández; Miriam Molina Rivero; Alessandra Queiroga Gonçalves; Emma Padilla; Josefa Pérez; Roger García-Puig; Tomas M Perez-Porcuna
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2019-11-11       Impact factor: 4.077
  6 in total

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