Amal Mohammed Husein Mackawy1, Bushra Mohammed Al-Ayed2, Bashayer Mater Al-Rashidi2. 1. Assistant Professor of Medical Biochemistry, Medical Laboratory Department, Applied Medical Science College, Qassim University, Saudi Arabia. 2. Students in the Medical Laboratory Department, Applied Medical Science College, Qassim University, Saudi Arabia.
Abstract
OBJECTIVES: Vitamin D deficiency is a global health problem, its role as an immune modulator has been recently emphasized. The evidence is increasingly pointing towards vitamin D significant role in reducing the incidence of autoimmune diseases. However, at this time the research on its role in autoimmune and thyroid disease is not conclusive. We aimed to examine the relationship between hypothyroidism and vitamin D deficiency and to clarify the relation between serum calcium levels with hypothyroid disease. SUBJECTS AND METHODS: Serum vitamin D (25-OH) levels were measured in 30 patients with hypothyroidism and 30 healthy subjects, utilizing the spectrophotometric method. Vitamin D deficiency was designated at levels lower than 20 ng/ml. Thyroid hormones (TSH, T3 and T4) and calcium levels were evaluated in all participants. RESULTS: Serum 25(OH) vit D was significantly lower in hypothyroid patients than in controls (t=-11.128, P =0.000). Its level was insignificantly decreased in females than male patients (t=- 1.32, P >0.05). Moreover, serum calcium levels recorded a significant decrease in hypothyroid patients when compared to controls (t= -5.69, P = 0.000). CONCLUSION: Our results indicated that patients with hypothyroidism suffered from hypovitaminosis D with hypocalcaemia that is significantly associated with the degree and severity of the hypothyroidism. That encourages the advisability of vit D supplementation and recommends the screening for Vitamin D deficiency and serum calcium levels for all hypothyroid patients.
OBJECTIVES:Vitamin D deficiency is a global health problem, its role as an immune modulator has been recently emphasized. The evidence is increasingly pointing towards vitamin D significant role in reducing the incidence of autoimmune diseases. However, at this time the research on its role in autoimmune and thyroid disease is not conclusive. We aimed to examine the relationship between hypothyroidism and vitamin D deficiency and to clarify the relation between serum calcium levels with hypothyroid disease. SUBJECTS AND METHODS: Serum vitamin D (25-OH) levels were measured in 30 patients with hypothyroidism and 30 healthy subjects, utilizing the spectrophotometric method. Vitamin D deficiency was designated at levels lower than 20 ng/ml. Thyroid hormones (TSH, T3 and T4) and calcium levels were evaluated in all participants. RESULTS: Serum 25(OH) vit D was significantly lower in hypothyroidpatients than in controls (t=-11.128, P =0.000). Its level was insignificantly decreased in females than male patients (t=- 1.32, P >0.05). Moreover, serum calcium levels recorded a significant decrease in hypothyroidpatients when compared to controls (t= -5.69, P = 0.000). CONCLUSION: Our results indicated that patients with hypothyroidism suffered from hypovitaminosis D with hypocalcaemia that is significantly associated with the degree and severity of the hypothyroidism. That encourages the advisability of vit D supplementation and recommends the screening for Vitamin D deficiency and serum calcium levels for all hypothyroidpatients.
Entities:
Keywords:
Blood calcium levels; Thyroid diseases; Vit D deficiency
Authors: Núria Vilarrasa; Joan Vendrell; Javier Maravall; Iñaki Elío; Esther Solano; Patricia San José; Isabel García; Núria Virgili; Juan Soler; José Manuel Gómez Journal: Endocrine Date: 2010-07-23 Impact factor: 3.633
Authors: T Kobayashi; T Okano; S Shida; K Okada; T Suginohara; H Nakao; E Kuroda; S Kodama; T Matsuo Journal: J Nutr Sci Vitaminol (Tokyo) Date: 1983-06 Impact factor: 2.000
Authors: G Muscogiuri; G Tirabassi; G Bizzaro; F Orio; S A Paschou; A Vryonidou; G Balercia; Y Shoenfeld; A Colao Journal: Eur J Clin Nutr Date: 2014-12-17 Impact factor: 4.016
Authors: Tim J van den Broek; Bas H A Kremer; Marisa Marcondes Rezende; Femke P M Hoevenaars; Peter Weber; Ulrich Hoeller; Ben van Ommen; Suzan Wopereis Journal: Genes Nutr Date: 2017-02-08 Impact factor: 5.523
Authors: Giovanna Muscogiuri; Daniela Mari; Silvia Prolo; Letizia M Fatti; Maria Celeste Cantone; Paolo Garagnani; Beatrice Arosio; Carolina Di Somma; Giovanni Vitale Journal: Int J Environ Res Public Health Date: 2016-08-26 Impact factor: 3.390