Literature DB >> 24532907

Local anesthetic systemic toxicity (LAST) - Should we not be concerned?

Rakhee Goyal1, R N Shukla2.   

Abstract

Local anesthetics are one of the most commonly used drugs in the field of medicine. Yet little is known about the systemic toxicity that can occur with their overdose. In the last few years, a lot of research has taken place understanding the etiology of the Local anesthetics systemic toxicity (LAST) and the role of lipid emulsion in treating it. There is a need to increase the awareness about LAST and establish a protocol to treat any serious neuro or cardiotoxicity.

Entities:  

Keywords:  Bupivacaine; Lignocaine; Lipid emulsion; Local anesthetics systemic toxicity (LAST)

Year:  2012        PMID： 24532907      PMCID： PMC3862663          DOI： 10.1016/j.mjafi.2012.02.011

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN： 0377-1237


  21 in total

Review 1.  Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009.

Authors:  Guido Di Gregorio; Joseph M Neal; Richard W Rosenquist; Guy L Weinberg
Journal:  Reg Anesth Pain Med       Date:  2010 Mar-Apr       Impact factor: 6.288

2.  Lipid rescue in resuscitation of local anesthetic-induced cardiac arrest in aesthetic surgery.

Authors:  Daniel Man; Vinod K Podichetty
Journal:  Plast Reconstr Surg       Date:  2010-06       Impact factor: 4.730

Review 3.  Local anesthetic systemic toxicity.

Authors:  Derek Dillane; Brendan T Finucane
Journal:  Can J Anaesth       Date:  2010-02-12       Impact factor: 5.063

4.  Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats.

Authors:  G L Weinberg; T VadeBoncouer; G A Ramaraju; M F Garcia-Amaro; M J Cwik
Journal:  Anesthesiology       Date:  1998-04       Impact factor: 7.892

Review 5.  ASRA practice advisory on local anesthetic systemic toxicity.

Authors:  Joseph M Neal; Christopher M Bernards; John F Butterworth; Guido Di Gregorio; Kenneth Drasner; Michael R Hejtmanek; Michael F Mulroy; Richard W Rosenquist; Guy L Weinberg
Journal:  Reg Anesth Pain Med       Date:  2010 Mar-Apr       Impact factor: 6.288

6.  Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion.

Authors:  Stephanie K Dix; Gregg F Rosner; Monica Nayar; Julian J Harris; Maya E Guglin; Jeffery R Winterfield; Zhiling Xiong; Gilbert H Mudge
Journal:  Crit Care Med       Date:  2011-04       Impact factor: 7.598

7.  Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart.

Authors:  Guy L Weinberg; Richard Ripper; Patricia Murphy; Lucas B Edelman; William Hoffman; Gary Strichartz; Douglas L Feinstein
Journal:  Reg Anesth Pain Med       Date:  2006 Jul-Aug       Impact factor: 6.288

8.  Cardiac electrophysiologic properties of bupivacaine and lidocaine compared with those of ropivacaine, a new amide local anesthetic.

Authors:  R Moller; B G Covino
Journal:  Anesthesiology       Date:  1990-02       Impact factor: 7.892

9.  Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid.

Authors:  G Foxall; R McCahon; J Lamb; J G Hardman; N M Bedforth
Journal:  Anaesthesia       Date:  2007-05       Impact factor: 6.955

10.  Prevention of local anesthetic systemic toxicity.

Authors:  Sandhya Yaddanapudi
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2011-10
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  2 in total

1.  Safety and Efficacy of Bupivacaine HCl Collagen-Matrix Implant (INL-001) in Open Inguinal Hernia Repair: Results from Two Randomized Controlled Trials.

Authors:  Vic Velanovich; Paul Rider; Kenneth Deck; Harold S Minkowitz; David Leiman; Nigel Jones; Gwendolyn Niebler
Journal:  Adv Ther       Date:  2018-11-22       Impact factor: 3.845

2.  An in vitro study of the release capacity of the local anaesthetics from siloxane matrices.

Authors:  Gabriela Preda; Alexandru Florin Rogobete; Dorel Săndesc; Ovidiu Horea Bedreag; Carmen Alina Cradigati; Mirela Sarandan; Marius Papurica; Sonia Elena Popovici; Monica Dragomirescu
Journal:  Rom J Anaesth Intensive Care       Date:  2016-10
  2 in total

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