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Literature DB >> 24532877

Metabolic acidosis due to inhaled salbutamol toxicity: A hazardous side effect complicating management of suspected cases of acute severe asthma.

Abstract

Metabolic acidosis has seldom been reported during treatment of asthma with use of beta agonist but not with much clinical consequence. We report two cases of metabolic acidosis with hyperventilation as a direct effect of salbutamol that caused difficulty in assessment and management of their respiratory symptoms which resolved with appropriate tapering of beta agonist.

Entities: Chemical Disease

Keywords: Acute asthma; Metabolic acidosis; Salbutamol toxicity

Year: 2012 PMID： 24532877 PMCID： PMC3862915 DOI： 10.1016/j.mjafi.2011.10.002

Source DB: PubMed Journal: Med J Armed Forces India ISSN： 0377-1237

11 in total

1. Diabetic ketoacidosis associated with oral salbutamol overdose.

Authors: George S Habib; Walid R Saliba; Leon Cohen
Journal: Am J Med Date: 2002-12-01 Impact factor: 4.965

2. Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.

Authors: G J Rodrigo; C Rodrigo
Journal: Emerg Med J Date: 2005-06 Impact factor: 2.740

3. Metabolic acidosis, respiratory distress, and children with severe acute asthma.

Authors: Padmanabhan Ramnarayan; Rajeev Chhabra; Prabhat Maheshwari
Journal: Pediatr Crit Care Med Date: 2009-01 Impact factor: 3.624

Review 4. Lactic acidosis and status asthmaticus: how common in pediatrics?

Authors: Ejaz Yousef; Stephen J McGeady
Journal: Ann Allergy Asthma Immunol Date: 2002-12 Impact factor: 6.347

Review 5. Pharmacogenomics of beta2-agonist: key focus on signaling pathways.

Authors: Pallav Bhatnagar; Randeep Guleria; Ritushree Kukreti
Journal: Pharmacogenomics Date: 2006-09 Impact factor: 2.533

Review 6. Lactic acidosis in status asthmaticus : three cases and review of the literature.

Authors: C A Manthous
Journal: Chest Date: 2001-05 Impact factor: 9.410

7. Cardiotoxicity during treatment of severe childhood asthma.

Authors: J F Maguire; P P O'Rourke; S D Colan; R S Geha; R Crone
Journal: Pediatrics Date: 1991-12 Impact factor: 7.124

Review 8. Asthma in childhood.

Authors: Paul D Robinson; Peter Van Asperen
Journal: Pediatr Clin North Am Date: 2009-02 Impact factor: 3.278

9. The effects of terbutaline on acid base, serum electrolytes, and glucose homeostasis during the management of preterm labor.

Authors: D B Cotton; H T Strassner; L G Lipson; D A Goldstein
Journal: Am J Obstet Gynecol Date: 1981-11-15 Impact factor: 8.661

Metabolic acidosis due to inhaled salbutamol toxicity: A hazardous side effect complicating management of suspected cases of acute severe asthma.

1. Diabetic ketoacidosis associated with oral salbutamol overdose.

2. Elevated plasma lactate level associated with high dose inhaled albuterol therapy in acute severe asthma.

3. Metabolic acidosis, respiratory distress, and children with severe acute asthma.

Review 4. Lactic acidosis and status asthmaticus: how common in pediatrics?

Review 5. Pharmacogenomics of beta2-agonist: key focus on signaling pathways.

Review 6. Lactic acidosis in status asthmaticus : three cases and review of the literature.

7. Cardiotoxicity during treatment of severe childhood asthma.

Review 8. Asthma in childhood.

9. The effects of terbutaline on acid base, serum electrolytes, and glucose homeostasis during the management of preterm labor.

Review 10. Lactic acidosis in asthma: report of two cases and review of the literature.

1. Acute salbutamol toxicity in the emergency department: A case report.

2. Salbutamol-Induced QT Interval Prolongation in a Two-Year-Old Patient.

Review 3. New perspectives of volemic resuscitation in polytrauma patients: a review.

4. Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis.