Literature DB >> 2453244

Effects of diuretics on GABA-gated chloride current in frog isolated sensory neurones.

N Inomata1, T Ishihara, N Akaike.   

Abstract

1. Effects of three diuretics (furosemide, amiloride and alpha-human atrial natriuretic polypeptide (alpha-hANP] on GABA-activated chloride current (ICl) were investigated in frog isolated sensory neurones, following suppression of Na+, K+ and Ca2+ currents, by use of a 'concentration-clamp' technique. 2. Furosemide inhibited the GABA-activated ICl in a non-competitive manner and facilitated the inactivation phase, while amiloride inhibited the GABA response in a competitive manner, both inhibitions being concentration-dependent. Alpha-hANP had no effects on the GABA-induced ICl. 3. The reversal potential of GABA-activated ICl (EGABA) was not shifted in the presence of amiloride or furosemide. 4. The results suggest that amiloride may act at the GABA binding site while furosemide may act on the GABA-gated chloride channel.

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Year:  1988        PMID： 2453244      PMCID： PMC1853826          DOI： 10.1111/j.1476-5381.1988.tb10326.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  25 in total

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6.  Furosemide inhibition of chloride transport in human red blood cells.

Authors:  P C Brazy; R B Gunn
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7.  Sodium-dependent suppression of gamma-aminobutyric-acid-gated chloride currents in internally perfused frog sensory neurones.

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9.  Characterization and ionic basis of GABA-induced depolarizations recorded in vitro from cat primary afferent neurones.

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10.  'Concentration-clamp' study of gamma-aminobutyric-acid-induced chloride current kinetics in frog sensory neurones.

Authors:  N Akaike; M Inoue; O A Krishtal
Journal:  J Physiol       Date:  1986-10       Impact factor: 5.182
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  5 in total

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