Literature DB >> 24532221

Targeted in vivo imaging of microscopic tumors with ferritin-based nanoprobes across biological barriers.

Changqian Cao1, Xuxia Wang, Yao Cai, Lei Sun, Lanxiang Tian, Hao Wu, Xiaoqing He, Hao Lei, Weifeng Liu, Guanjun Chen, Rixiang Zhu, Yongxin Pan.   

Abstract

The avascular microscopic breast and brain tumors (<1-2 mm diameter) can be noninvasively detected by designing human heavy-chain ferritin (HFn)-based nanoparticles as molecular probes for near-infrared fluorescence and magnetic resonance imaging. The intravenously injected HFn-based nano-particles (Cy5.5-HFn and M-HFn) can cross the endothelium, epithelium, and blood-brain barriers and be internalized into tumor cells.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  biological barrier; ferritin; iron oxide nanoparticles; molecular imaging; tumor

Mesh：

Substances：

Year:  2014        PMID： 24532221     DOI： 10.1002/adma.201304544

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  16 in total

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Review 3.  Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting.

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Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-04       Impact factor: 11.205

Review 6.  Ferritins as nanoplatforms for imaging and drug delivery.

Authors:  Zipeng Zhen; Wei Tang; Trever Todd; Jin Xie
Journal:  Expert Opin Drug Deliv       Date:  2014-07-29       Impact factor: 6.648

7.  Enhanced magnetic resonance imaging and staining of cancer cells using ferrimagnetic H-ferritin nanoparticles with increasing core size.

Authors:  Yao Cai; Changqian Cao; Xiaoqing He; Caiyun Yang; Lanxiang Tian; Rixiang Zhu; Yongxin Pan
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Journal:  Sci Rep       Date:  2016-06-01       Impact factor: 4.379

Review 9.  Cancer stem cells and strategies for targeted drug delivery.

Authors:  Jin Cao; Shubhmita Bhatnagar; Jiawei Wang; Xueyong Qi; Swayam Prabha; Jayanth Panyam
Journal:  Drug Deliv Transl Res       Date:  2020-10-23       Impact factor: 5.671

10.  A comparative study of neurotoxic potential of synthesized polysaccharide-coated and native ferritin-based magnetic nanoparticles.

Authors:  Arseniy Borysov; Natalia Krisanova; Olexander Chunihin; Ludmila Ostapchenko; Nataliya Pozdnyakova; Tatiana Borisova
Journal:  Croat Med J       Date:  2014-06-01       Impact factor: 1.351
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