Literature DB >> 24531327

Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.

Jay Gunawardana1, Fong Chun Chan2, Adèle Telenius3, Bruce Woolcock3, Robert Kridel1, King L Tan3, Susana Ben-Neriah3, Anja Mottok3, Raymond S Lim3, Merrill Boyle3, Sanja Rogic4, Lisa M Rimsza5, Chrystelle Guiter6, Karen Leroy7, Philippe Gaulard7, Corinne Haioun8, Marco A Marra9, Kerry J Savage3, Joseph M Connors3, Sohrab P Shah10, Randy D Gascoyne1, Christian Steidl1.   

Abstract

Classical Hodgkin lymphoma and primary mediastinal B cell lymphoma (PMBCL) are related lymphomas sharing pathological, molecular and clinical characteristics. Here we discovered by whole-genome and whole-transcriptome sequencing recurrent somatic coding-sequence mutations in the PTPN1 gene. Mutations were found in 6 of 30 (20%) Hodgkin lymphoma cases, in 6 of 9 (67%) Hodgkin lymphoma-derived cell lines, in 17 of 77 (22%) PMBCL cases and in 1 of 3 (33%) PMBCL-derived cell lines, consisting of nonsense, missense and frameshift mutations. We demonstrate that PTPN1 mutations lead to reduced phosphatase activity and increased phosphorylation of JAK-STAT pathway members. Moreover, silencing of PTPN1 by RNA interference in Hodgkin lymphoma cell line KM-H2 resulted in hyperphosphorylation and overexpression of downstream oncogenic targets. Our data establish PTPN1 mutations as new drivers in lymphomagenesis.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24531327     DOI： 10.1038/ng.2900

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  62 in total

Review 1.  Primary mediastinal B-cell lymphoma.

Authors:  Peter W M Johnson; Andrew J Davies
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2008

Review 2.  PTP1B: a double agent in metabolism and oncogenesis.

Authors:  Shu-Chin Yip; Sayanti Saha; Jonathan Chernoff
Journal:  Trends Biochem Sci       Date:  2010-04-08       Impact factor: 13.807

3.  STAT3 is constitutively activated in Hodgkin cell lines.

Authors:  D Kube; U Holtick; M Vockerodt; T Ahmadi; B Haier; I Behrmann; P C Heinrich; V Diehl; H Tesch
Journal:  Blood       Date:  2001-08-01       Impact factor: 22.113

4.  BRAF mutations in hairy-cell leukemia.

Authors:  Enrico Tiacci; Vladimir Trifonov; Gianluca Schiavoni; Antony Holmes; Wolfgang Kern; Maria Paola Martelli; Alessandra Pucciarini; Barbara Bigerna; Roberta Pacini; Victoria A Wells; Paolo Sportoletti; Valentina Pettirossi; Roberta Mannucci; Oliver Elliott; Arcangelo Liso; Achille Ambrosetti; Alessandro Pulsoni; Francesco Forconi; Livio Trentin; Gianpietro Semenzato; Giorgio Inghirami; Monia Capponi; Francesco Di Raimondo; Caterina Patti; Luca Arcaini; Pellegrino Musto; Stefano Pileri; Claudia Haferlach; Susanne Schnittger; Giovanni Pizzolo; Robin Foà; Laurent Farinelli; Torsten Haferlach; Laura Pasqualucci; Raul Rabadan; Brunangelo Falini
Journal:  N Engl J Med       Date:  2011-06-11       Impact factor: 91.245

5.  Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.

Authors:  Tingting Sun; Nicola Aceto; Kristen L Meerbrey; Jessica D Kessler; Chunshui Zhou; Ilenia Migliaccio; Don X Nguyen; Natalya N Pavlova; Maria Botero; Jian Huang; Ronald J Bernardi; Earlene Schmitt; Guang Hu; Mamie Z Li; Noah Dephoure; Steven P Gygi; Mitchell Rao; Chad J Creighton; Susan G Hilsenbeck; Chad A Shaw; Donna Muzny; Richard A Gibbs; David A Wheeler; C Kent Osborne; Rachel Schiff; Mohamed Bentires-Alj; Stephen J Elledge; Thomas F Westbrook
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

6.  Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.

Authors:  Noriko Koyama; Steffen Koschmieder; Sandhya Tyagi; Ignacio Portero-Robles; Jörg Chromic; Silke Myloch; Heike Nürnberger; Tanja Rossmanith; Wolf-Karsten Hofmann; Dieter Hoelzer; Oliver Gerhard Ottmann
Journal:  Clin Cancer Res       Date:  2006-04-01       Impact factor: 12.531

Review 7.  Genome sequencing of lymphoid malignancies.

Authors:  Charles G Mullighan
Journal:  Blood       Date:  2013-09-16       Impact factor: 22.113

8.  Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas.

Authors:  J R Wiener; J A Hurteau; B J Kerns; R S Whitaker; M R Conaway; A Berchuck; R C Bast
Journal:  Am J Obstet Gynecol       Date:  1994-04       Impact factor: 8.661

9.  Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data.

Authors:  Jiarui Ding; Ali Bashashati; Andrew Roth; Arusha Oloumi; Kane Tse; Thomas Zeng; Gholamreza Haffari; Martin Hirst; Marco A Marra; Anne Condon; Samuel Aparicio; Sohrab P Shah
Journal:  Bioinformatics       Date:  2011-11-13       Impact factor: 6.937

10.  Searching for SNPs with cloud computing.

Authors:  Ben Langmead; Michael C Schatz; Jimmy Lin; Mihai Pop; Steven L Salzberg
Journal:  Genome Biol       Date:  2009-11-20       Impact factor: 13.583
View more
  59 in total

Review 1.  Ontogeny, Genetics, Molecular Biology, and Classification of B- and T-Cell Non-Hodgkin Lymphoma.

Authors:  Russell James Hubbard Ryan; Ryan Alan Wilcox
Journal:  Hematol Oncol Clin North Am       Date:  2019-05-18       Impact factor: 3.722

2.  Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.

Authors:  Enrico Tiacci; Erik Ladewig; Gianluca Schiavoni; Alex Penson; Elisabetta Fortini; Valentina Pettirossi; Yuchun Wang; Ariele Rosseto; Alessandra Venanzi; Sofija Vlasevska; Roberta Pacini; Simonetta Piattoni; Alessia Tabarrini; Alessandra Pucciarini; Barbara Bigerna; Alessia Santi; Alessandro M Gianni; Simonetta Viviani; Antonello Cabras; Stefano Ascani; Barbara Crescenzi; Cristina Mecucci; Laura Pasqualucci; Raul Rabadan; Brunangelo Falini
Journal:  Blood       Date:  2018-04-12       Impact factor: 22.113

3.  PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

Authors:  Jaewoo Choi; Anita Saraf; Laurence Florens; Michael P Washburn; Luca Busino
Journal:  Cell Cycle       Date:  2018-09-25       Impact factor: 4.534

Review 4.  Clinical utility of recently identified diagnostic, prognostic, and predictive molecular biomarkers in mature B-cell neoplasms.

Authors:  Arantza Onaindia; L Jeffrey Medeiros; Keyur P Patel
Journal:  Mod Pathol       Date:  2017-06-30       Impact factor: 7.842

5.  Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy.

Authors:  Thomas Menter; Alexandar Tzankov
Journal:  Virchows Arch       Date:  2018-08-21       Impact factor: 4.064

Review 6.  Signaling pathways and immune evasion mechanisms in classical Hodgkin lymphoma.

Authors:  W Robert Liu; Margaret A Shipp
Journal:  Blood       Date:  2017-11-23       Impact factor: 22.113

Review 7.  Primary mediastinal B-cell lymphoma: biology and evolving therapeutic strategies.

Authors:  Kieron Dunleavy
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2017-12-08

Review 8.  Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach?

Authors:  Kieron Dunleavy; Wyndham H Wilson
Journal:  Blood       Date:  2014-12-11       Impact factor: 22.113

9.  Recurrent somatic loss of TNFRSF14 in classical Hodgkin lymphoma.

Authors:  Stephen J Salipante; Andrew Adey; Anju Thomas; Choli Lee; Yajuan J Liu; Akash Kumar; Alexandra P Lewis; David Wu; Jonathan R Fromm; Jay Shendure
Journal:  Genes Chromosomes Cancer       Date:  2015-12-09       Impact factor: 5.006

Review 10.  The immune microenvironment in Hodgkin lymphoma: T cells, B cells, and immune checkpoints.

Authors:  Santosha Vardhana; Anas Younes
Journal:  Haematologica       Date:  2016-07       Impact factor: 9.941
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.