Gemma Chiva-Blanch1, Ximena Condines2, Emma Magraner2, Irene Roth1, Palmira Valderas-Martínez1, Sara Arranz1, Rosa Casas1, Miriam Martínez-Huélamo3, Anna Vallverdú-Queralt3, Paola Quifer-Rada3, Rosa M Lamuela-Raventos3, Ramon Estruch4. 1. Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036 Barcelona, Spain; CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain. 2. Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts (AS), GESCLINIC, Barcelona, Spain. 3. CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain; Nutrition and Food Science Department, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain. 4. Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Villarroel 170, 08036 Barcelona, Spain; CIBER CB06/03 Fisiopatología de la Obesidad y la Nutrición, (CIBERobn) and RETIC RD06/0045, Spain. Electronic address: restruch@clinic.ub.es.
Abstract
RATIONALE: Moderate alcohol consumption is associated with a decrease in cardiovascular risk, but fermented beverages seem to confer greater cardiovascular protection due to their polyphenolic content. Circulating endothelial progenitor cells (EPC) are bone-marrow-derived stem cells with the ability to repair and maintain endothelial integrity and function and are considered as a surrogate marker of vascular function and cumulative cardiovascular risk. Nevertheless, no study has been carried out on the effects of moderate beer consumption on the number of circulating EPC in high cardiovascular risk patients. OBJECTIVE: To compare the effects of moderate consumption of beer, non-alcoholic beer and gin on the number of circulating EPC and EPC-mobilizing factors. METHODS: In this crossover trial, 33 men at high cardiovascular risk were randomized to receive beer (30 g alcohol/d), the equivalent amount of polyphenols in the form of non-alcoholic beer, or gin (30 g alcohol/d) for 4 weeks. Diet and physical exercise were carefully monitored. RESULTS: The number of circulating EPC and EPC-mobilizing factors were determined at baseline and after each intervention. After the beer and non-alcoholic beer interventions, the number of circulating EPC significantly increased by 8 and 5 units, respectively, while no significant differences were observed after the gin period. In correlation, stromal cell derived factor 1 increased significantly after the non-alcoholic and the beer interventions. CONCLUSIONS: The non-alcoholic fraction of beer increases the number of circulating EPC in peripheral blood from high cardiovascular risk subjects. CLINICAL TRIAL REGISTRATION: http://www.controlled-trials.com/ISRCTN95345245 ISRCTN95345245.
RCT Entities:
RATIONALE: Moderate alcohol consumption is associated with a decrease in cardiovascular risk, but fermented beverages seem to confer greater cardiovascular protection due to their polyphenolic content. Circulating endothelial progenitor cells (EPC) are bone-marrow-derived stem cells with the ability to repair and maintain endothelial integrity and function and are considered as a surrogate marker of vascular function and cumulative cardiovascular risk. Nevertheless, no study has been carried out on the effects of moderate beer consumption on the number of circulating EPC in high cardiovascular risk patients. OBJECTIVE: To compare the effects of moderate consumption of beer, non-alcoholic beer and gin on the number of circulating EPC and EPC-mobilizing factors. METHODS: In this crossover trial, 33 men at high cardiovascular risk were randomized to receive beer (30 g alcohol/d), the equivalent amount of polyphenols in the form of non-alcoholic beer, or gin (30 g alcohol/d) for 4 weeks. Diet and physical exercise were carefully monitored. RESULTS: The number of circulating EPC and EPC-mobilizing factors were determined at baseline and after each intervention. After the beer and non-alcoholic beer interventions, the number of circulating EPC significantly increased by 8 and 5 units, respectively, while no significant differences were observed after the gin period. In correlation, stromal cell derived factor 1 increased significantly after the non-alcoholic and the beer interventions. CONCLUSIONS: The non-alcoholic fraction of beer increases the number of circulating EPC in peripheral blood from high cardiovascular risk subjects. CLINICAL TRIAL REGISTRATION: http://www.controlled-trials.com/ISRCTN95345245 ISRCTN95345245.
Authors: Nuria García-Marchena; Pedro Fernando Araos; Vicente Barrios; Laura Sánchez-Marín; Julie A Chowen; María Pedraz; Estela Castilla-Ortega; Pablo Romero-Sanchiz; Guillermo Ponce; Ana L Gavito; Juan Decara; Daniel Silva; Marta Torrens; Jesús Argente; Gabriel Rubio; Antonia Serrano; Fernando Rodríguez de Fonseca; Francisco Javier Pavón Journal: Front Psychiatry Date: 2017-01-18 Impact factor: 4.157