Toru Miyoshi1, Masayuki Doi2, Shinichi Usui3, Mutsumi Iwamoto2, Masahito Kajiya2, Ko Takeda2, Kazumasa Nosaka2, Rie Nakayama2, Keisuke Okawa2, Wataru Takagi2, Kazufumi Nakamura4, Satoshi Hirohata5, Hiroshi Ito4. 1. Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan. Electronic address: miyoshit@cc.okayama-u.ac.jp. 2. Department of Cardiology, Kagawa Prefectural Central Hospital, Kagawa, Japan. 3. Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan. 4. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. 5. International Center, Okayama University, Okayama, Japan.
Abstract
OBJECTIVE: Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine that is associated with insulin resistance in animals. To extend these observations to humans, we investigated the association of serum SFRP5 levels in subjects with and without coronary artery disease (CAD). METHODS: Subjects (n=185, 68±11 years, 79% male) suspected of having CAD were enrolled in the study and were divided into two groups, CAD and non-CAD subjects, according to the results of their coronary angiographies. Serum SFRP5 levels of the subjects were measured by an enzyme-linked immunosorbent assay. RESULTS: The serum SFRP5 levels in the subjects with CAD were significantly lower than those in the non-CAD subjects (median [interquartile range]: 47.7 [26.6] vs. 52.4 [29.6] ng/mL, respectively; p=0.02). The serum SFRP5 levels significantly correlated with body mass index, the homeostasis model of assessment of insulin resistance, adiponectin levels, and CAD severity. Multivariate logistic regression analysis revealed that a decreased serum SFRP5 level (log transformed) was independently associated with CAD for all subjects (adjusted odds ratio, 0.36; 95% confidence interval, 0.14-0.94; p=0.03). CONCLUSION: Serum SFRP5 levels are significantly associated with CAD in humans, suggesting that low SFRP5 levels may contribute to CAD.
OBJECTIVE:Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine that is associated with insulin resistance in animals. To extend these observations to humans, we investigated the association of serum SFRP5 levels in subjects with and without coronary artery disease (CAD). METHODS: Subjects (n=185, 68±11 years, 79% male) suspected of having CAD were enrolled in the study and were divided into two groups, CAD and non-CAD subjects, according to the results of their coronary angiographies. Serum SFRP5 levels of the subjects were measured by an enzyme-linked immunosorbent assay. RESULTS: The serum SFRP5 levels in the subjects with CAD were significantly lower than those in the non-CAD subjects (median [interquartile range]: 47.7 [26.6] vs. 52.4 [29.6] ng/mL, respectively; p=0.02). The serum SFRP5 levels significantly correlated with body mass index, the homeostasis model of assessment of insulin resistance, adiponectin levels, and CAD severity. Multivariate logistic regression analysis revealed that a decreased serum SFRP5 level (log transformed) was independently associated with CAD for all subjects (adjusted odds ratio, 0.36; 95% confidence interval, 0.14-0.94; p=0.03). CONCLUSION: Serum SFRP5 levels are significantly associated with CAD in humans, suggesting that low SFRP5 levels may contribute to CAD.
Authors: Melissa G Farb; Shakun Karki; Song-Young Park; Samantha M Saggese; Brian Carmine; Donald T Hess; Caroline Apovian; Jessica L Fetterman; Rosa Bretón-Romero; Naomi M Hamburg; José J Fuster; María A Zuriaga; Kenneth Walsh; Noyan Gokce Journal: Vasc Med Date: 2016-09-28 Impact factor: 3.239
Authors: Maren Carstensen-Kirberg; Julia M Kannenberg; Cornelia Huth; Christa Meisinger; Wolfgang Koenig; Margit Heier; Annette Peters; Wolfgang Rathmann; Michael Roden; Christian Herder; Barbara Thorand Journal: Cardiovasc Diabetol Date: 2017-08-29 Impact factor: 9.951