| Literature DB >> 24530685 |
Shaojun Zhu1, Zhipeng Wang2, Zhipei Zhang3, Jian Wang4, Yanhong Li5, Li Yao6, Qibing Mei7, Wei Zhang8.
Abstract
Esophageal squamous cell carcinomas (ESCCs) are highly invasive and have poor prognoses. We investigated the role of PTPLAD2, a protein tyrosine phosphatase-like A domain (PTPLAD) family member, in ESCC carcinogenesis. Survival analysis was performed using patient data. ESCC tissue samples lost PTPLAD2 heterozygosity and had decreased PTPLAD2 expression. Low PTPLAD2 expression and high p-STAT3 correlated with poor prognosis. Overexpression of PTPLAD2 in ESCC cells reduced STAT3 phosphorylation, decreased FoxM1, inhibited proliferation and decreased in mouse xenograft tumor formation. Therefore, PTPLAD2 is a potential tumor suppressor and prognostic indicator that reduces STAT3 phosphorylation. PTPLAD2 is a possible clinical target for ESCC treatment.Entities:
Keywords: Esophageal cancer; PTPLAD2; Prognosis; Proliferation; Signal transducer and activator of transcription 3
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Year: 2014 PMID： 24530685 DOI： 10.1016/j.febslet.2014.01.058
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124