| Literature DB >> 24530512 |
Hironobu Yasui1, Ryo Takeuchi1, Masaki Nagane1, Shunsuke Meike1, Yoshinari Nakamura1, Tohru Yamamori1, Yoshinori Ikenaka2, Yasuhiro Kon3, Hiroki Murotani4, Motoi Oishi4, Yukio Nagasaki4, Osamu Inanami5.
Abstract
High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatment increased the levels of reproductive cell death and apoptosis induced by X-irradiation. GNG accumulated in cytoplasm and increased the expression of endoplasmic reticulum (ER) stress-related protein. GNG suppressed the repair capacity of DNA after X-irradiation by down-regulating DNA repair-related proteins. Our results suggest that GNG radiosensitized cells by enhancing apoptosis and impairing DNA repair capacity via ER stress induction.Entities:
Keywords: Apoptosis; DNA repair; Endoplasmic reticulum stress; Gold nanoparticle; Radiation
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Year: 2014 PMID： 24530512 DOI： 10.1016/j.canlet.2014.02.005
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679