Literature DB >> 24530492

Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents.

Afreen Inam1, Shadab Miyan Siddiqui1, Taís Soares Macedo2, Diogo Rodrigo Magalhaes Moreira2, Ana Cristina Lima Leite3, Milena Botelho Pereira Soares4, Amir Azam5.   

Abstract

N-Acylhydrazones derived from 7-chloro-4-piperazin-1-yl-quinoline were synthesized and biologically evaluated for blood-stage of Plasmodium falciparum and Entamoeba histolytica trophozoites. N-Acylhydrazone F12 was found to inhibit the P. falciparum growth as well as its life cycle with good selectivity, which was achieved by inhibiting hematin formation. Compound F24 showed better IC50 value than the amoebicidal drug metronidazole.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Acylhydrazone; Aminoquinoline; Amoebiasis; Malaria; Piperazinyl derivatives

Mesh：

Substances：

Year:  2014        PMID： 24530492     DOI： 10.1016/j.ejmech.2014.01.023

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  Evaluation of antiplasmodial activity in silico and in vitro of N-acylhydrazone derivatives.

Authors:  Fernanda A Oliveira; Ana Claudia S Pinto; Caique L Duarte; Alex G Taranto; Eder Lorenzato Junior; Cleydson Finotti Cordeiro; Diogo T Carvalho; Fernando P Varotti; Amanda L Fonseca
Journal:  BMC Chem       Date:  2022-07-09

Review 2.  Hydrazide-hydrazones as potential antimicrobial agents: overview of the literature since 2010.

Authors:  Łukasz Popiołek
Journal:  Med Chem Res       Date:  2016-11-25       Impact factor: 1.965

3.  Effective methods for the synthesis of hydrazones, quinazolines, and Schiff bases: reaction monitoring using a chemometric approach.

Authors:  Jana Pisk; Ivica Đilović; Tomica Hrenar; Danijela Cvijanović; Gordana Pavlović; Višnja Vrdoljak
Journal:  RSC Adv       Date:  2020-10-20       Impact factor: 4.036

4.  In Vitro Anticancer Screening, Molecular Docking and Antimicrobial Studies of Triazole-Based Nickel(II) Metal Complexes.

Authors:  Sachin A Deodware; Umesh B Barache; Pratibha C Dhale; Kundalkesha D Gaikwad; Chandan Shivamallu; Panchsheela A Ubale; Ali A Shati; Mohammad Y Alfaifi; Serag Eldin I Elbehairi; Raghu Ram Achar; Ekaterina Silina; Victor Stupin; Juan Frau; Norma Flores-Holguín; Shashikant H Gaikwad; Shiva Prasad Kollur; Daniel Glossman-Mitnik
Journal:  Molecules       Date:  2022-10-03       Impact factor: 4.927

Review 5.  Parasitic diarrheal disease: drug development and targets.

Authors:  Amir Azam; Mudasir N Peerzada; Kamal Ahmad
Journal:  Front Microbiol       Date:  2015-10-27       Impact factor: 5.640

6.  Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies.

Authors:  Hui Yu; Wei Zhang; Qing Yu; Fu-Ping Huang; He-Dong Bian; Hong Liang
Journal:  Molecules       Date:  2017-10-24       Impact factor: 4.411

Review 7.  Recent Advances in the Discovery of Novel Antiprotozoal Agents.

Authors:  Seong-Min Lee; Min-Sun Kim; Faisal Hayat; Dongyun Shin
Journal:  Molecules       Date:  2019-10-28       Impact factor: 4.411
  7 in total

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