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Literature DB >> 24530298

Galectin-3 in cancer.

Lin Song¹, Jian-wu Tang², Lawrence Owusu³, Ming-Zhong Sun³, Jun Wu¹, Jun Zhang¹.

Abstract

Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-3 as well as its potential action mechanism in tumorigenesis in a variety of cancers were summarized and concluded. Gal-3 is gaining its attraction as a potential new biomarker for the diagnosis, treatment and prognosis of certain tumors.

Entities: Disease Gene

Keywords: Cancer; Expression; Galectin-3 (Gal-3); Location; Mechanism

Mesh：

Substances：

Year: 2014 PMID： 24530298 DOI： 10.1016/j.cca.2014.01.019

Source DB: PubMed Journal: Clin Chim Acta ISSN： 0009-8981 Impact factor: 3.786

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Cited

49 in total

Review 1. Biomarkers for risk prediction in acute decompensated heart failure.

Authors: A Rogier van der Velde; Wouter C Meijers; Rudolf A de Boer
Journal: Curr Heart Fail Rep Date: 2014-09

2. Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signaling activation.

Authors: Guoqing Cai; Xiangdong Ma; Biliang Chen; Yanhong Huang; Shujuan Liu; Hong Yang; Wei Zou
Journal: Tumour Biol Date: 2016-04-08

3. Bergenin: a computationally proven promising scaffold for novel galectin-3 inhibitors.

Authors: Ranga Srinath Jayakody; Prageeth Wijewardhane; Chamikara Herath; Shehani Perera
Journal: J Mol Model Date: 2018-10-02 Impact factor: 1.810

4. Studies on the role of goat heart galectin-1 as a tool for detecting post-malignant changes in glycosylation pattern.

Authors: Ghulam Md Ashraf; Asma Perveen; Shams Tabrez; Syed Kashif Zaidi; Mohammad A Kamal; Naheed Banu
Journal: Saudi J Biol Sci Date: 2014-08-12 Impact factor: 4.219

5. Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling.

Authors: Moustafa Gabr; Ashfaq Ur Rehman; Hai-Feng Chen
Journal: ACS Med Chem Lett Date: 2020-08-11 Impact factor: 4.345

6. Galectin-3 rs4652 A>C polymorphism is associated with the risk of gastric carcinoma and P-glycoprotein expression level.

Authors: Yi Shi; Xiandong Lin; Gang Chen; Jun Yan; Mingang Ying; Xiongwei Zheng
Journal: Oncol Lett Date: 2017-10-23 Impact factor: 2.967

Galectin-3 in cancer.

Review 1. Biomarkers for risk prediction in acute decompensated heart failure.

2. Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signaling activation.

3. Bergenin: a computationally proven promising scaffold for novel galectin-3 inhibitors.

4. Studies on the role of goat heart galectin-1 as a tool for detecting post-malignant changes in glycosylation pattern.

5. Quinoline-Pyrazole Scaffold as a Novel Ligand of Galectin-3 and Suppressor of TREM2 Signaling.

6. Galectin-3 rs4652 A>C polymorphism is associated with the risk of gastric carcinoma and P-glycoprotein expression level.

7. Chlamydophila psittaci-negative ocular adnexal marginal zone lymphomas express self polyreactive B-cell receptors.

8. Galectin-3 N-terminal tail prolines modulate cell activity and glycan-mediated oligomerization/phase separation.

9. Elevated plasma galectin-3 levels and their correlation with disease activity in adult-onset Still's disease.

10. Effect of lgals3a on embryo development of zebrafish.