Perrine Parize1, Sandrine Billaud2, Anne L Bienvenu3, Stéphanie Bourdy4, Marie A le Pogam4, Philippe Reix5, Stéphane Picot3, Raymond Robert2, Olivier Lortholary6, Jean-Philippe Bouchara7, Isabelle Durieu8. 1. Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Adult Cystic Fibrosis Reference Center, 69495 Pierre-Bénite, France; Université de Lyon, Lyon, France. Electronic address: perrine.parize@nck.aphp.fr. 2. L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Institut de Biologie en Santé-IRIS, 49933 Angers, France. 3. Hospices Civils de Lyon, Service de Parasitologie et de Mycologie Médicale, 69317 Lyon, France; University Lyon 1, Malaria Research Unit, ICBMS, CNRS UMR, 69373 Lyon, France. 4. Hospices Civils de Lyon, Pôle IMER, Université de Lyon, 69424 Lyon, France. 5. Université de Lyon, Lyon, France; Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Pediatric Cystic Fibrosis Reference Center, 69500 Bron, France. 6. Université Paris-Descartes, Hôpital Necker-Enfants malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, IHU Imagine, 75015 Paris, France. 7. L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Institut de Biologie en Santé-IRIS, 49933 Angers, France; Laboratoire de Parasitologie-Mycologie, Institut de Biologie en Santé-PBH, Centre Hospitalier Universitaire, 49933 Angers, France. 8. Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Adult Cystic Fibrosis Reference Center, 69495 Pierre-Bénite, France.
Abstract
BACKGROUND: Species of the Scedosporium apiospermum complex (S. a complex) are emerging fungi responsible for chronic airway colonization in cystic fibrosis (CF) patients. Recent studies performed on Aspergillus fumigatus suggest that the colonization of the airways by filamentous fungi may contribute to the progressive deterioration of lung function. METHODS: We studied S. a complex seroprevalence, as a marker of close contact between patient and the fungi, in a large monocentric cohort of CF patients attended in a reference centre in Lyon, France. RESULTS: Serum samples from 373 CF patients were analysed. Antibodies against S. a complex were detected in 35 patients (9.4%). In multivariate analysis, S. a complex seropositivity was only associated with seropositivity to A. fumigatus. CONCLUSIONS: This study does not suggest an association between sensitization against S. a complex and poorer lung function in CF. Prospective studies are needed to evaluate the impact of both seropositivity and S. a complex colonization on the course of CF.
BACKGROUND: Species of the Scedosporium apiospermum complex (S. a complex) are emerging fungi responsible for chronic airway colonization in cystic fibrosis (CF) patients. Recent studies performed on Aspergillus fumigatus suggest that the colonization of the airways by filamentous fungi may contribute to the progressive deterioration of lung function. METHODS: We studied S. a complex seroprevalence, as a marker of close contact between patient and the fungi, in a large monocentric cohort of CFpatients attended in a reference centre in Lyon, France. RESULTS: Serum samples from 373 CFpatients were analysed. Antibodies against S. a complex were detected in 35 patients (9.4%). In multivariate analysis, S. a complex seropositivity was only associated with seropositivity to A. fumigatus. CONCLUSIONS: This study does not suggest an association between sensitization against S. a complex and poorer lung function in CF. Prospective studies are needed to evaluate the impact of both seropositivity and S. a complex colonization on the course of CF.
Authors: Sven D Willger; Sharon L Grim; Emily L Dolben; Anna Shipunova; Thomas H Hampton; Hilary G Morrison; Laura M Filkins; George A O'Toole; Lisa A Moulton; Alix Ashare; Mitchell L Sogin; Deborah A Hogan Journal: Microbiome Date: 2014-11-03 Impact factor: 14.650