| Literature DB >> 24530110 |
Davide Lonati1, Eleonora Buscaglia2, Pietro Papa3, Antonella Valli3, Teresa Coccini4, Andrea Giampreti2, Valeria Margherita Petrolini2, Sarah Vecchio2, Giovanni Serpelloni5, Carlo Alessandro Locatelli2.
Abstract
Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a "legally" obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).Entities:
Mesh：
Substances：
Year: 2014 PMID： 24530110 DOI： 10.1016/j.annemergmed.2014.01.007
Source DB: PubMed Journal: Ann Emerg Med ISSN： 0196-0644 Impact factor: 5.721