Helena H Askling1, Lars Rombo2, Ronald van Vollenhoven3, Ingemar Hallén4, Åke Thörner5, Margareta Nordin6, Christian Herzog7, Anu Kantele8. 1. Karolinska Institutet, Dept. of Medicine/Solna, Unit for Infectious Diseases, SE 17176 Stockholm, Sweden; Dept. of Communicable Diseases Control and Prevention, SE 118 91 Stockholm, Sweden. Electronic address: helena.hervius-askling@sll.se. 2. Karolinska Institutet, Dept. of Medicine/Solna, Unit for Infectious Diseases, SE 17176 Stockholm, Sweden; Centre for Clinical Research, Sörmland, Uppsala University, SE 631 88 Eskilstuna, Sweden. Electronic address: lars.rombo@telia.com. 3. Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Karolinska Institutet, SE-17176 Stockholm Sweden. Electronic address: ronald.van.vollenhoven@ki.se. 4. Dept. of Infectious Diseases, Karlstad County Hospital, SE 651 85 Karlstad, Sweden. Electronic address: ingemar.hallen@liv.se. 5. Dept. of Rheumatology, Mälar Hospital, SE 631 88 Eskilstuna, Sweden. Electronic address: ake.thorner@dll.se. 6. Dept. of Clinical Microbiology, Karolinska University Hospital, SE 17176 Stockholm, Sweden. Electronic address: margareta.nordin@karolinska.se. 7. Swiss Tropical and Public Health Institute, CH-4051 Basel, Switzerland. Electronic address: herzog.ch47@gmail.com. 8. Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, FI-00029 HUCH Helsinki, Finland; Department of Medicine, FI-00014 University of Helsinki, Finland. Electronic address: anu.kantele@hus.fi.
Abstract
BACKGROUND: Hepatitis A vaccine is the most frequently used travel vaccine, yet data are scarce about its ability to induce protection in patients with concurrent immunosuppressive treatment. We assessed the immunogenicity of this vaccine in rheumatoid arthritis (RA) patients treated with tumour necrosis factor-inhibitors (TNFi) and/or methotrexate (MTX). METHODS: Hepatitis A vaccine was administered to non-immune RA patients at 0 and 6 months. Hepatitis A virus (HAV) antibodies were assessed at 0, 1, 6, 7, 12, and 24 months with a quantitative Chemiluminescent Microparticle Immuno Assay (CMIA) for HAV-IgG. Samples from month 1, 6, and 7 were, in addition, analysed with a microparticle EIA (MEIA) for anti-HAV IgM + IgG. RESULTS: The final study population consisted of 53 patients treated with TNFi (n = 15), TNFi + MTX (n = 21) or MTX (n = 17). One and six months after the first dose, 10% and 33% of the patients had attained seroprotection. One and six months after the second dose 83% and 72% were seroprotected. At month 24, 86% of the vaccinees showed protective levels. CONCLUSIONS: Two doses of hepatitis A vaccine at a 6-month interval provided protection for most immunosuppressed RA patients. A single dose does not seem to afford sufficient protection to this group of patients.
BACKGROUND:Hepatitis A vaccine is the most frequently used travel vaccine, yet data are scarce about its ability to induce protection in patients with concurrent immunosuppressive treatment. We assessed the immunogenicity of this vaccine in rheumatoid arthritis (RA) patients treated with tumour necrosis factor-inhibitors (TNFi) and/or methotrexate (MTX). METHODS:Hepatitis A vaccine was administered to non-immune RApatients at 0 and 6 months. Hepatitis A virus (HAV) antibodies were assessed at 0, 1, 6, 7, 12, and 24 months with a quantitative Chemiluminescent Microparticle Immuno Assay (CMIA) for HAV-IgG. Samples from month 1, 6, and 7 were, in addition, analysed with a microparticle EIA (MEIA) for anti-HAV IgM + IgG. RESULTS: The final study population consisted of 53 patients treated with TNFi (n = 15), TNFi + MTX (n = 21) or MTX (n = 17). One and six months after the first dose, 10% and 33% of the patients had attained seroprotection. One and six months after the second dose 83% and 72% were seroprotected. At month 24, 86% of the vaccinees showed protective levels. CONCLUSIONS: Two doses of hepatitis A vaccine at a 6-month interval provided protection for most immunosuppressed RApatients. A single dose does not seem to afford sufficient protection to this group of patients.
Authors: Yu Bin Seo; Su Jin Moon; Chan Hong Jeon; Joon Young Song; Yoon Kyoung Sung; Su Jin Jeong; Ki Tae Kwon; Eu Suk Kim; Jae Hoon Kim; Hyoun Ah Kim; Dong Jin Park; Sung Hoon Park; Jin Kyun Park; Joong Kyong Ahn; Ji Seon Oh; Jae Won Yun; Joo Hyun Lee; Hee Young Lee; Min Joo Choi; Won Suk Choi; Young Hwa Choi; Jung Hyun Choi; Jung Yeon Heo; Hee Jin Cheong; Shin Seok Lee Journal: Infect Chemother Date: 2020-06
Authors: Kim A Papp; Boulos Haraoui; Deepali Kumar; John K Marshall; Robert Bissonnette; Alain Bitton; Brian Bressler; Melinda Gooderham; Vincent Ho; Shahin Jamal; Janet E Pope; A Hillary Steinhart; Donald C Vinh; John Wade Journal: J Cutan Med Surg Date: 2018-11-21 Impact factor: 2.092
Authors: Christien Rondaan; Victoria Furer; Marloes W Heijstek; Nancy Agmon-Levin; Marc Bijl; Ferdinand C Breedveld; Raffaele D'Amelio; Maxime Dougados; Meliha C Kapetanovic; Jacob M van Laar; Annette Ladefoged de Thurah; Robert Landewé; Anna Molto; Ulf Müller-Ladner; Karen Schreiber; Leo Smolar; Jim Walker; Klaus Warnatz; Nico M Wulffraat; Sander van Assen; Ori Elkayam Journal: RMD Open Date: 2019-09-09