Paul M Ridker1, Nancy R Cook2. 1. Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiology, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: pridker@partners.org. 2. Center for Cardiovascular Disease Prevention, Divisions of Preventive Medicine and Cardiology, Brigham and Women's Hospital, Boston, MA 02215, USA.