| Literature DB >> 24529368 |
Don Benjamin1, Michael N Hall2.
Abstract
mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.Entities:
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Year: 2014 PMID： 24529368 DOI： 10.1016/j.cell.2014.01.057
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582