Literature DB >> 2452935

Analysis of antibody microprobe autoradiographs by computerized image processing.

I A Hendry1, C R Morton, A W Duggan.   

Abstract

A computerized digitizing method to analyze the autoradiographs derived from the antibody microprobe technique is described. The method enables the averaging of groups of microprobes that have been placed in similar locations in the central nervous system during the same physiological stimulation. Control and experimental groups of microprobes can be compared, and a level of significance for the release of a neuropeptide obtained. In addition estimates can be made of the concentration of peptide present in regions of release.

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Year:  1988        PMID： 2452935     DOI： 10.1016/0165-0270(88)90009-x

Source DB:  PubMed          Journal:  J Neurosci Methods        ISSN： 0165-0270            Impact factor:   2.390


  6 in total

1.  Analgesic doses of morphine do not reduce noxious stimulus-evoked release of immunoreactive neurokinins in the dorsal horn of the spinal cat.

Authors:  C W Lang; A W Duggan; P J Hope
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739

2.  Neuropeptide Y-like substances are released from the rostral brainstem of cats during the muscle pressor response.

Authors:  C A Williams
Journal:  J Physiol       Date:  1996-08-15       Impact factor: 5.182

3.  Absence of tonic supraspinal control of substance P release in the substantia gelatinosa of the anaesthetized cat.

Authors:  A W Duggan; C R Morton; W D Hutchison; I A Hendry
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

4.  Morphine and substance P release in the spinal cord.

Authors:  C R Morton; W D Hutchison; A W Duggan; I A Hendry
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

5.  C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons.

Authors:  Xiaohui Ding; Fang Hua; Kristopher Sutherly; Jeffrey L Ardell; Carole A Williams
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-08-27       Impact factor: 3.619

6.  Lack of effect of microinjection of noradrenaline or medetomidine on stimulus-evoked release of substance P in the spinal cord of the cat: a study with antibody microprobes.

Authors:  C W Lang; P J Hope; B D Grubb; A W Duggan
Journal:  Br J Pharmacol       Date:  1994-07       Impact factor: 8.739
  6 in total

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