Kazuhiko Tsuruya1, Hisako Yoshida2, Masaharu Nagata3, Takanari Kitazono4, Hideki Hirakata5, Kunitoshi Iseki6, Toshiki Moriyama7, Kunihiro Yamagata8, Hideaki Yoshida9, Shouichi Fujimoto10, Koichi Asahi11, Issei Kurahashi12, Yasuo Ohashi13, Tsuyoshi Watanabe14. 1. Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tsuruya@intmed2.med.kyushu-u.ac.jp. 2. Department of Integrated Therapy for Chronic Kidney Disease, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: hisako@kcu.med.kyushu-u.ac.jp. 3. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: masanaga@envmed.med.kyushu-u.ac.jp. 4. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: kitazono@intmed2.med.kyushu-u.ac.jp. 5. Division of Nephrology and Dialysis Center, Japanese Red Cross Fukuoka Hospital, 3-1-1 Okusu, Minami-ku, Fukuoka 815-8555, Japan. Electronic address: hhirakata@fukuoka-med.jrc.or.jp. 6. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: chihokun@med.u-ryukyu.ac.jp. 7. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: moriyama@wellness.hss.osaka-u.ac.jp. 8. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: k-yamaga@md.tsukuba.ac.jp. 9. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: yoshihi@sapmed.ac.jp. 10. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: fujimos@fc.miyazaki-u.ac.jp. 11. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: asahi@fmu.ac.jp. 12. Department of Planning, Information, and Management, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Electronic address: kurahashi@epistat.m.u-tokyo.ac.jp. 13. Department of Biostatistics, School of Public Health, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: ohashi@epistat.m.u-tokyo.ac.jp. 14. Steering Committee for the Examination of the Positioning of CKD in Specific Health Check and Guidance, 3-28-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: twat0423@fmu.ac.jp.
Abstract
OBJECTIVES: To investigate the relationship between triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) and chronic kidney disease (CKD). METHODS: We used data from 216,007 Japanese adults who participated in a nationwide health checkup program. Men (n = 88,516) and women (n = 127,491) were grouped into quartiles based on their TG/HDL-C levels (<1.26, 1.26-1.98, 1.99-3.18, and >3.18 in men; <0.96, 0.96-1.44, 1.45-2.22, and >2.22 in women). We cross-sectionally assessed the association of TG/HDL-C levels with CKD [defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2) (low eGFR) and/or proteinuria (defined as urinary protein ≥ 1+ on dipstick testing)], low eGFR, and proteinuria. RESULTS: The prevalence of CKD, low eGFR, and proteinuria increased significantly with elevating quartiles of TG/HDL-C in both genders (all P for trend <0.001). Participants in the highest quartile of TG/HDL-C had a significantly greater risk of CKD than those in the lowest quartile after adjustment for the relevant confounding factors (odds ratio: 1.57, 95% confidence interval: 1.49-1.65 in men; 1.41, 1.34-1.48 in women, respectively). Furthermore, there were significant associations with low eGFR and proteinuria. In stratified analysis, the risk of CKD increased linearly with greater TG/HDL-C levels in participants with and without hypertension, diabetes, and obesity. Moreover, higher TG/HDL-C levels were relevant for CKD, especially in participants with hypertension and diabetes (P for interaction <0.001, respectively). CONCLUSIONS: An elevated TG/HDL-C is associated with the risk of CKD in the Japanese population.
OBJECTIVES: To investigate the relationship between triglycerides to high-density lipoprotein cholesterol ratio (TG/HDL-C) and chronic kidney disease (CKD). METHODS: We used data from 216,007 Japanese adults who participated in a nationwide health checkup program. Men (n = 88,516) and women (n = 127,491) were grouped into quartiles based on their TG/HDL-C levels (<1.26, 1.26-1.98, 1.99-3.18, and >3.18 in men; <0.96, 0.96-1.44, 1.45-2.22, and >2.22 in women). We cross-sectionally assessed the association of TG/HDL-C levels with CKD [defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2) (low eGFR) and/or proteinuria (defined as urinary protein ≥ 1+ on dipstick testing)], low eGFR, and proteinuria. RESULTS: The prevalence of CKD, low eGFR, and proteinuria increased significantly with elevating quartiles of TG/HDL-C in both genders (all P for trend <0.001). Participants in the highest quartile of TG/HDL-C had a significantly greater risk of CKD than those in the lowest quartile after adjustment for the relevant confounding factors (odds ratio: 1.57, 95% confidence interval: 1.49-1.65 in men; 1.41, 1.34-1.48 in women, respectively). Furthermore, there were significant associations with low eGFR and proteinuria. In stratified analysis, the risk of CKD increased linearly with greater TG/HDL-C levels in participants with and without hypertension, diabetes, and obesity. Moreover, higher TG/HDL-C levels were relevant for CKD, especially in participants with hypertension and diabetes (P for interaction <0.001, respectively). CONCLUSIONS: An elevated TG/HDL-C is associated with the risk of CKD in the Japanese population.
Authors: Y Ohashi; R Tai; T Aoki; S Mizuiri; T Ogura; Y Tanaka; T Okada; A Aikawa; K Sakai Journal: J Nutr Health Aging Date: 2015-12 Impact factor: 4.075
Authors: Seok Hui Kang; Da Jung Jung; Kyu Hyang Cho; Jong Won Park; Kyung Woo Yoon; Jun Young Do Journal: PLoS One Date: 2015-03-20 Impact factor: 3.240