Literature DB >> 2452901

Expression of the gag-pol fusion protein of Moloney murine leukemia virus without gag protein does not induce virion formation or proteolytic processing.

K M Felsenstein1, S P Goff.   

Abstract

A mutant of Moloney murine leukemia virus was generated in which the UAG termination codon at the 3' end of the gag gene was changed to a CAG codon encoding glutamine. Cells carrying the mutant provirus constitutively express the gag-pol fusion protein and no detectable gag protein. The precursor is stable, is not processed by the protease domain within the precursor, and does not induce assembly and release of virion particles.

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Year:  1988        PMID： 2452901      PMCID： PMC253323     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Authors:  M Wigler; R Sweet; G K Sim; B Wold; A Pellicer; E Lacy; T Maniatis; S Silverstein; R Axel
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

2.  Translation of MuLV and MSV RNAs in nuclease-treated reticulocyte extracts: enhancement of the gag-pol polypeptide with yeast suppressor tRNA.

Authors:  L Philipson; P Andersson; U Olshevsky; R Weinberg; D Baltimore; R Gesteland
Journal:  Cell       Date:  1978-01       Impact factor: 41.582

3.  Sequence and spacing requirements of a retrovirus integration site.

Authors:  J Colicelli; S P Goff
Journal:  J Mol Biol       Date:  1988-01-05       Impact factor: 5.469

4.  Enchancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran.

Authors:  J H McCutchan; J S Pagano
Journal:  J Natl Cancer Inst       Date:  1968-08       Impact factor: 13.506

5.  Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.

Authors:  S Goff; P Traktman; D Baltimore
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

6.  Further characterization of intracellular precursor polyproteins of Rauscher leukemia virus.

Authors:  G A Jamjoom; R B Naso; R B Arlinghaus
Journal:  Virology       Date:  1977-05-01       Impact factor: 3.616

7.  "gag" polyprotein precursors of Rauscher murine leukemia virus.

Authors:  L J Arcement; W L Karshin; R B Naso; R B Arlinghaus
Journal:  Virology       Date:  1977-09       Impact factor: 3.616

8.  Cell-free synthesis of a precursor polyprotein containing both gag and pol gene products by Rauscher murine leukemia virus 35S RNA.

Authors:  E C Murphy; J J Kopchick; K F Watson; R B Arlinghaus
Journal:  Cell       Date:  1978-02       Impact factor: 41.582

9.  High frequency of aberrant expression of Moloney murine leukemia virus in clonal infections.

Authors:  A Shields; W N Witte; E Rothenberg; D Baltimore
Journal:  Cell       Date:  1978-07       Impact factor: 41.582

10.  Relationship of retrovirus polyprotein cleavages to virion maturation studied with temperature-sensitive murine leukemia virus mutants.

Authors:  O N Witte; D Baltimore
Journal:  J Virol       Date:  1978-06       Impact factor: 5.103
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  74 in total

Review 1.  Translational control of viral gene expression in eukaryotes.

Authors:  M Gale; S L Tan; M G Katze
Journal:  Microbiol Mol Biol Rev       Date:  2000-06       Impact factor: 11.056

2.  Transposition of a Ty3 GAG3-POL3 fusion mutant is limited by availability of capsid protein.

Authors:  J Kirchner; S B Sandmeyer; D B Forrest
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

3.  Mutational analysis of the gag-pol junction of Moloney murine leukemia virus: requirements for expression of the gag-pol fusion protein.

Authors:  K M Felsenstein; S P Goff
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

4.  Matrix protein of Akv murine leukemia virus: genetic mapping of regions essential for particle formation.

Authors:  E C Jørgensen; F S Pedersen; P Jørgensen
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

5.  Complementation studies with Rous sarcoma virus gag and gag-pol polyprotein mutants.

Authors:  S Oertle; N Bowles; P F Spahr
Journal:  J Virol       Date:  1992-06       Impact factor: 5.103

6.  Foamy virus Pol protein expressed as a Gag-Pol fusion retains enzymatic activities, allowing for infectious virus production.

Authors:  Eun-Gyung Lee; Amber Sinicrope; Dana L Jackson; Shuyuarn F Yu; Maxine L Linial
Journal:  J Virol       Date:  2012-04-04       Impact factor: 5.103

7.  Identification of a cellular factor that modulates HIV-1 programmed ribosomal frameshifting.

Authors:  Yoshifumi Kobayashi; Jianling Zhuang; Stuart Peltz; Joseph Dougherty
Journal:  J Biol Chem       Date:  2010-04-23       Impact factor: 5.157

8.  Gag mutations can impact virological response to dual-boosted protease inhibitor combinations in antiretroviral-naïve HIV-infected patients.

Authors:  Lucile Larrouy; C Chazallon; R Landman; C Capitant; G Peytavin; G Collin; C Charpentier; A Storto; G Pialoux; C Katlama; P M Girard; P Yeni; J P Aboulker; F Brun-Vezinet; D Descamps
Journal:  Antimicrob Agents Chemother       Date:  2010-05-03       Impact factor: 5.191

9.  Achieving a golden mean: mechanisms by which coronaviruses ensure synthesis of the correct stoichiometric ratios of viral proteins.

Authors:  Ewan P Plant; Rasa Rakauskaite; Deborah R Taylor; Jonathan D Dinman
Journal:  J Virol       Date:  2010-02-17       Impact factor: 5.103

10.  Profile of Stephen P. Goff. Interview by Greg Williams.

Authors:  Stephen P Goff
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-13       Impact factor: 11.205
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