| Literature DB >> 24528709 |
Vineet Kumar Rai1, Narayan Prasad Yadav2, Priyam Sinha1, Nidhi Mishra1, Suaib Luqman3, Harinath Dwivedi4, Koshy M Kymonil4, Shubhini A Saraf5.
Abstract
Aim of the present investigation was to develop cellulosic polymer based mucoadhesive antifungal gel comprising novel ternary mixture of miconazole nitrate (MN) for buccal delivery. Crosslinking of gel was made by adjusting pH with triethanolamine (TEA) and gel formulation was optimized on the basis of flux of MN (0.562-1.751 mg/cm(2)/h) calculated from ex vivo permeation study. Based on statistically validated polynomial equation and plotted response surfaces, B17 was found to be the optimum batch. Texture profile in terms of adhesiveness (3.24 ± 0.012 g), firmness (10.83 ± 0.067 g), spreadability (3.63 ± 0.033 mJ) and extrudability (35.6 ± 0.1 mJ) of B17 was evaluated using a novel instrumental approach. The texture parameters were found to be consistent over 90 days. Ternary mixture containing gel showed broader zone of growth inhibition (32.67-47.33 mm) in comparison to marketed formulation containing pure MN (17.50-40.33 mm) against selected strains of fungi. In conclusion, consistent and effective mucoadhesive antifungal gel of MN with extended residence time in oral mucosa was developed.Entities:
Keywords: Buccal delivery; Ex vivo permeation; Miconazole nitrate; Mucoadhesive antifungal gel; Ternary mixture; Texture analysis
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Year: 2013 PMID： 24528709 DOI： 10.1016/j.carbpol.2013.12.019
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381