Thaís de Salgado Rêgo1, Louise da Silva Ash1, Letícia Pessoa1, Márcia Barreto da Silva Feijó2, Juliana Leite3, Aline de Sousa dos Santos4, Carlos Alberto Soares da Costa1, Gilson Teles Boaventura1. 1. Experimental Nutrition Laboratory. College of Nutrition. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com. 2. Bromatology Laboratory. College of Pharmacy. Federal Fluminense University. Niterói. Rio de Janeiro. Brazil.. thais.nutricionista@ymail.com. 3. Department of Pathology and Veterinary Clinics. Veterinary Faculty. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com. 4. Physiological Sciences Department. Institute of Biology Roberto Alcantara Gomes. State University of Rio de Janeiro. Brazil. thais.nutricionista@ymail.com.
Abstract
INTRODUCTION: Diabetic patients have a higher risk to osteoporotic fractures. Foods, such as yam, to oppose hyperglycemia, has been used to treatment of diabetes. OBJECTIVE: The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on glycemia and bone parameters of female diabetic rats. METHODS: Female Wistar rats with 3 months age were allocated in three groups. Control group (C, n = 6), treated with normal fat diet. Diabetic rats treated with high-fat diet without (DM, n = 8) and with (DMY, n = 8) liofilized yam flour. After 5 weeks of the experiment, serum glucose and insulin, pancreas mass, number and area of pancreas islets were quantified. And femur parameters were analyzed by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). RESULTS: Differences were considered significant if P<0.05. Diabetic groups showed lower (P < 0.05): femur and pancreas mass, area of the pancreatic islets and insulin. However, DMY showed lower (-10%, P < 0.05) concentrations of glucose to DM group. Femur, by DXA, showed lower bone mineral density, content and area in the DM group. While the DMY group showed greater (+27%, P < 0.05) radiodensity of femoral head when compared to DM group. DISCUSSION: Brazilian yam flour supplement did not fix a defect, but alleviated the consequences of the experimental diabetic disease. It showed results to control the rise in blood glucose levels in diabetic rats, suggesting protection in oxidative agents and postpone harm in the bone. CONCLUSION: Considering all the findings of the present study, our results suggest that yam flour does act producing benefits in the experimental diabetes. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
INTRODUCTION:Diabeticpatients have a higher risk to osteoporotic fractures. Foods, such as yam, to oppose hyperglycemia, has been used to treatment of diabetes. OBJECTIVE: The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on glycemia and bone parameters of female diabeticrats. METHODS: Female Wistar rats with 3 months age were allocated in three groups. Control group (C, n = 6), treated with normal fat diet. Diabeticrats treated with high-fat diet without (DM, n = 8) and with (DMY, n = 8) liofilized yam flour. After 5 weeks of the experiment, serum glucose and insulin, pancreas mass, number and area of pancreas islets were quantified. And femur parameters were analyzed by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). RESULTS: Differences were considered significant if P<0.05. Diabetic groups showed lower (P < 0.05): femur and pancreas mass, area of the pancreatic islets and insulin. However, DMY showed lower (-10%, P < 0.05) concentrations of glucose to DM group. Femur, by DXA, showed lower bone mineral density, content and area in the DM group. While the DMY group showed greater (+27%, P < 0.05) radiodensity of femoral head when compared to DM group. DISCUSSION: Brazilian yam flour supplement did not fix a defect, but alleviated the consequences of the experimental diabetic disease. It showed results to control the rise in blood glucose levels in diabeticrats, suggesting protection in oxidative agents and postpone harm in the bone. CONCLUSION: Considering all the findings of the present study, our results suggest that yam flour does act producing benefits in the experimental diabetes. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Lu Sun; Yuan Ming Di; Chuanjian Lu; Xinfeng Guo; Xianyu Tang; Anthony Lin Zhang; Charlie Changli Xue; Guanjie Fan Journal: Front Endocrinol (Lausanne) Date: 2020-11-10 Impact factor: 5.555