BACKGROUND: Smoking has been associated with improved outcome in thrombolysed patients with myocardial infarction and higher recanalization rates in stroke patients treated with tissue plasminogen activator (tPA). We hypothesized a positive association between smoking and favourable outcome in stroke patients treated with tPA and no such association in acute stroke patients not treated with tPA, suggesting a beneficial effect of smoking on thrombolysis with tPA. METHODS: Stroke patients treated with tPA and stroke patients not treated with tPA, but presenting within 6 h after stroke onset, were included in two separate groups. Three groups were defined according to smoking habits: current smoking, previous smoking and no smoking. Functional outcome by modified Rankin Scale (mRS) was assessed after 1 week or at discharge, if discharged earlier. Favourable outcome was defined as mRS 0 or 1. RESULTS: A total of 399 patients were treated with tPA (94 current smokers, 148 previous smokers and 157 non-smokers), whereas 424 patients were not treated with tPA (90 current smokers, 164 previous smokers and 170 non-smokers). Current smoking was independently associated with favourable outcome in patients treated with tPA when adjusted for confounders (OR 2.08, 95% CI 1.09-3.95, P = 0.025). There was no such association in acute stroke patients not treated with tPA (OR 1.26, 95% CI 0.67-2.36, P = 0.472). CONCLUSION: Our study showed an association between current smoking and favourable short-term outcome in stroke patients treated with tPA, but not in acute stroke patients not treated with tPA. This may indicate a more effective thrombolysis with tPA in smokers.
BACKGROUND: Smoking has been associated with improved outcome in thrombolysed patients with myocardial infarction and higher recanalization rates in strokepatients treated with tissue plasminogen activator (tPA). We hypothesized a positive association between smoking and favourable outcome in strokepatients treated with tPA and no such association in acute strokepatients not treated with tPA, suggesting a beneficial effect of smoking on thrombolysis with tPA. METHODS:Strokepatients treated with tPA and strokepatients not treated with tPA, but presenting within 6 h after stroke onset, were included in two separate groups. Three groups were defined according to smoking habits: current smoking, previous smoking and no smoking. Functional outcome by modified Rankin Scale (mRS) was assessed after 1 week or at discharge, if discharged earlier. Favourable outcome was defined as mRS 0 or 1. RESULTS: A total of 399 patients were treated with tPA (94 current smokers, 148 previous smokers and 157 non-smokers), whereas 424 patients were not treated with tPA (90 current smokers, 164 previous smokers and 170 non-smokers). Current smoking was independently associated with favourable outcome in patients treated with tPA when adjusted for confounders (OR 2.08, 95% CI 1.09-3.95, P = 0.025). There was no such association in acute strokepatients not treated with tPA (OR 1.26, 95% CI 0.67-2.36, P = 0.472). CONCLUSION: Our study showed an association between current smoking and favourable short-term outcome in strokepatients treated with tPA, but not in acute strokepatients not treated with tPA. This may indicate a more effective thrombolysis with tPA in smokers.
Authors: H Nishi; N Hosomi; K Ohta; S Aoki; M Nakamori; T Nezu; H Shigeishi; T Shintani; T Obayashi; K Ishikawa; N Kinoshita; Y Shiga; M Sugiyama; H Ohge; H Maruyama; H Kawaguchi; H Kurihara Journal: Clin Exp Immunol Date: 2020-03-24 Impact factor: 4.330
Authors: Stewart J Wiseman; Fergus N Doubal; Francesca M Chappell; Maria C Valdés-Hernández; Xin Wang; Ann Rumley; Gordon D O Lowe; Martin S Dennis; Joanna M Wardlaw Journal: Cerebrovasc Dis Date: 2015-08-08 Impact factor: 2.762
Authors: Alexander Hammer; Anahi Steiner; Gholamreza Ranaie; Eduard Yakubov; Frank Erbguth; Christian M Hammer; Monika Killer-Oberpfalzer; Hans Steiner; Hendrik Janssen Journal: Sci Rep Date: 2018-08-17 Impact factor: 4.379