OBJECT: Chiari malformation Type I (CM-I) is a developmental abnormality often associated with a spinal syrinx. Patients with syringomyelia are known to have an increased risk of scoliosis, yet the influence of specific radiographically demonstrated features on the prevalence of scoliosis remains unclear. The primary objective of the present study was to investigate the relationship of maximum syrinx diameter and tonsillar descent to the presence of scoliosis in patients with CM-I-associated syringomyelia. A secondary objective was to explore the role of craniovertebral junction (CVJ) characteristics as additional risk factors for scoliosis. METHODS: The authors conducted a retrospective review of pediatric patients evaluated for CM-I with syringomyelia at a single institution in the period from 2000 to 2012. Syrinx morphology and CVJ parameters were evaluated with MRI, whereas the presence of scoliosis was determined using standard radiographic criteria. Multiple logistic regression was used to analyze radiological features that were independently associated with scoliosis. RESULTS: Ninety-two patients with CM-I and syringomyelia were identified. The mean age was 10.5 ± 5 years. Thirty-five (38%) of 92 patients had spine deformity; 23 (66%) of these 35 patients were referred primarily for deformity, and 12 (34%) were diagnosed with deformity during workup for other symptoms. Multiple regression analysis revealed maximum syrinx diameter > 6 mm (OR 12.1, 95% CI 3.63-40.57, p < 0.001) and moderate (5-12 mm) rather than severe (> 12 mm) tonsillar herniation (OR 7.64, 95% CI 2.3-25.31, p = 0.001) as significant predictors of spine deformity when controlling for age, sex, and syrinx location. CONCLUSIONS: The current study further elucidates the association between CM-I and spinal deformity by defining specific radiographic characteristics associated with the presence of scoliosis. Specifically, patients presenting with larger maximum syrinx diameters (> 6 mm) have an increased risk of scoliosis.
OBJECT: Chiari malformation Type I (CM-I) is a developmental abnormality often associated with a spinal syrinx. Patients with syringomyelia are known to have an increased risk of scoliosis, yet the influence of specific radiographically demonstrated features on the prevalence of scoliosis remains unclear. The primary objective of the present study was to investigate the relationship of maximum syrinx diameter and tonsillar descent to the presence of scoliosis in patients with CM-I-associated syringomyelia. A secondary objective was to explore the role of craniovertebral junction (CVJ) characteristics as additional risk factors for scoliosis. METHODS: The authors conducted a retrospective review of pediatric patients evaluated for CM-I with syringomyelia at a single institution in the period from 2000 to 2012. Syrinx morphology and CVJ parameters were evaluated with MRI, whereas the presence of scoliosis was determined using standard radiographic criteria. Multiple logistic regression was used to analyze radiological features that were independently associated with scoliosis. RESULTS: Ninety-two patients with CM-I and syringomyelia were identified. The mean age was 10.5 ± 5 years. Thirty-five (38%) of 92 patients had spine deformity; 23 (66%) of these 35 patients were referred primarily for deformity, and 12 (34%) were diagnosed with deformity during workup for other symptoms. Multiple regression analysis revealed maximum syrinx diameter > 6 mm (OR 12.1, 95% CI 3.63-40.57, p < 0.001) and moderate (5-12 mm) rather than severe (> 12 mm) tonsillar herniation (OR 7.64, 95% CI 2.3-25.31, p = 0.001) as significant predictors of spine deformity when controlling for age, sex, and syrinx location. CONCLUSIONS: The current study further elucidates the association between CM-I and spinal deformity by defining specific radiographic characteristics associated with the presence of scoliosis. Specifically, patients presenting with larger maximum syrinx diameters (> 6 mm) have an increased risk of scoliosis.
Authors: Jacob K Greenberg; Chester K Yarbrough; Alireza Radmanesh; Jakub Godzik; Megan Yu; Donna B Jeffe; Matthew D Smyth; Tae Sung Park; Jay F Piccirillo; David D Limbrick Journal: Neurosurgery Date: 2015-03 Impact factor: 4.654
Authors: H Alexander; D Tsering; J S Myseros; S N Magge; C Oluigbo; C E Sanchez; Robert F Keating Journal: Childs Nerv Syst Date: 2019-07-27 Impact factor: 1.475
Authors: Gabe Haller; Brooke Sadler; Timothy Kuensting; Nivan Lakshman; Jacob K Greenberg; Jennifer M Strahle; Tae Sung Park; Matthew B Dobbs; Christina A Gurnett; David D Limbrick Journal: J Neurosurg Pediatr Date: 2020-04-10 Impact factor: 2.375
Authors: Travis S CreveCoeur; Alexander T Yahanda; Cormac O Maher; Gabrielle W Johnson; Laurie L Ackerman; P David Adelson; Raheel Ahmed; Gregory W Albert; Phillipp R Aldana; Tord D Alden; Richard C E Anderson; Lissa Baird; David F Bauer; Karin S Bierbrauer; Douglas L Brockmeyer; Joshua J Chern; Daniel E Couture; David J Daniels; Robert C Dauser; Susan R Durham; Richard G Ellenbogen; Ramin Eskandari; Herbert E Fuchs; Timothy M George; Gerald A Grant; Patrick C Graupman; Stephanie Greene; Jeffrey P Greenfield; Naina L Gross; Daniel J Guillaume; Gabe Haller; Todd C Hankinson; Gregory G Heuer; Mark Iantosca; Bermans J Iskandar; Eric M Jackson; Andrew H Jea; James M Johnston; Robert F Keating; Michael P Kelly; Nickalus Khan; Mark D Krieger; Jeffrey R Leonard; Francesco T Mangano; Timothy B Mapstone; J Gordon McComb; Arnold H Menezes; Michael Muhlbauer; W Jerry Oakes; Greg Olavarria; Brent R O'Neill; Tae Sung Park; John Ragheb; Nathan R Selden; Manish N Shah; Chevis Shannon; Joshua S Shimony; Jodi Smith; Matthew D Smyth; Scellig S D Stone; Jennifer M Strahle; Mandeep S Tamber; James C Torner; Gerald F Tuite; Scott D Wait; John C Wellons; William E Whitehead; David D Limbrick Journal: Neurosurgery Date: 2021-01-13 Impact factor: 4.654